PRDM4 mediates YAP‐induced cell invasion by activating leukocyte‐specific integrin β2 expression

Yes‐associated protein (YAP) is a transcriptional co‐activator and a major effector of the Hippo pathway that promotes cell proliferation and stemness, while inhibiting apoptosis. YAP plays a central role in organ size control, and its deregulation strongly promotes cancer initiation and progression...

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Published inEMBO reports Vol. 19; no. 6
Main Authors Liu, Huan, Dai, Xiaoming, Cao, Xiaolei, Yan, Huan, Ji, Xinyan, Zhang, Haitao, Shen, Shuying, Si, Yuan, Zhang, Hailong, Chen, Jianfeng, Li, Li, Zhao, Jonathan C, Yu, Jindan, Feng, Xin‐Hua, Zhao, Bin
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.06.2018
Springer Nature B.V
John Wiley and Sons Inc
Subjects
Adaptor Proteins, Signal Transducing - genetics
Adaptor Proteins, Signal Transducing - physiology
Animals
Apoptosis
Cancer
CD18 Antigens - metabolism
Cell growth
cell invasion
Cell Line, Tumor
Cell proliferation
Cell Proliferation - genetics
Deregulation
DNA-Binding Proteins - genetics
DNA-Binding Proteins - metabolism
EMBO03
EMBO37
Endothelium
Gene expression
Genes
Hippo pathway
Humans
ITGB2
Kinases
Leukocytes
Male
Metastases
Mice
Mimicry
Neoplasm Invasiveness
Phosphoproteins - genetics
Phosphoproteins - physiology
PRDM4
Prostate cancer
Prostatic Neoplasms - metabolism
Prostatic Neoplasms - pathology
Proteins
Scientific Report
Scientific Reports
Transcription activation
Transcription factors
Transcription Factors - genetics
Transcription Factors - metabolism
Tumorigenesis
Yes-associated protein
Hippo pathway
yes‐associated protein
cell invasion
PRDM4
ITGB2
Online AccessGet full text
ISSN1469-221X
1469-3178
1469-3178
DOI10.15252/embr.201745180

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Abstract Yes‐associated protein (YAP) is a transcriptional co‐activator and a major effector of the Hippo pathway that promotes cell proliferation and stemness, while inhibiting apoptosis. YAP plays a central role in organ size control, and its deregulation strongly promotes cancer initiation and progression. However, the mechanisms by which YAP promotes cell invasion and metastasis are not fully understood. Here, we report that YAP induces leukocyte‐specific integrin β2 ( ITGB2 ) expression in cancer cells, thereby promoting cell invasion through the endothelium in a manner mimicking leukocytes. Through independent biochemical purification and a functional screen, we further identified PR/SET domain 4 (PRDM4) as a transcription factor interacting with the WW domains of YAP to mediate ITGB2 expression and cell invasion. Consistently, ITGB2 and PRDM4 mRNA levels are significantly increased in metastatic prostate cancer. In addition, PRDM4 contributes to YAP‐induced tumorigenesis possibly via mediating the expression of other YAP target genes. Our results demonstrate that YAP promotes cell invasion by inducing leukocyte‐specific integrin expression, and identify PRDM4 as a novel transcription factor for YAP targets. Synopsis Yes‐associated protein (YAP) is a transcriptional co‐activator and major effector of the Hippo pathway, promoting cell proliferation and stemness. YAP interacts with PRDM4, thereby promoting transendothelial invasion of cancer cells by inducing expression of the leukocyte‐specific integrin ITGB2. PR/SET domain 4 (PRDM4) interacts with YAP to promote transcriptional activation of target genes. PRDM4 and TEAD co‐ordinately mediate the activation of the YAP target gene ITGB2. YAP‐induced ITGB2 expression promotes cancer cell invasion in a manner mimicking leukocytes. Graphical Abstract Yes‐associated protein (YAP) is a transcriptional co‐activator and major effector of the Hippo pathway, promoting cell proliferation and stemness. YAP interacts with PRDM4, thereby promoting transendothelial invasion of cancer cells by inducing expression of the leukocyte‐specific integrin ITGB2.
AbstractList Yes‐associated protein (YAP) is a transcriptional co‐activator and a major effector of the Hippo pathway that promotes cell proliferation and stemness, while inhibiting apoptosis. YAP plays a central role in organ size control, and its deregulation strongly promotes cancer initiation and progression. However, the mechanisms by which YAP promotes cell invasion and metastasis are not fully understood. Here, we report that YAP induces leukocyte‐specific integrin β2 (ITGB2) expression in cancer cells, thereby promoting cell invasion through the endothelium in a manner mimicking leukocytes. Through independent biochemical purification and a functional screen, we further identified PR/SET domain 4 (PRDM4) as a transcription factor interacting with the WW domains of YAP to mediate ITGB2 expression and cell invasion. Consistently, ITGB2 and PRDM4 mRNA levels are significantly increased in metastatic prostate cancer. In addition, PRDM4 contributes to YAP‐induced tumorigenesis possibly via mediating the expression of other YAP target genes. Our results demonstrate that YAP promotes cell invasion by inducing leukocyte‐specific integrin expression, and identify PRDM4 as a novel transcription factor for YAP targets.
Yes‐associated protein (YAP) is a transcriptional co‐activator and a major effector of the Hippo pathway that promotes cell proliferation and stemness, while inhibiting apoptosis. YAP plays a central role in organ size control, and its deregulation strongly promotes cancer initiation and progression. However, the mechanisms by which YAP promotes cell invasion and metastasis are not fully understood. Here, we report that YAP induces leukocyte‐specific integrin β2 ( ITGB2 ) expression in cancer cells, thereby promoting cell invasion through the endothelium in a manner mimicking leukocytes. Through independent biochemical purification and a functional screen, we further identified PR/SET domain 4 (PRDM4) as a transcription factor interacting with the WW domains of YAP to mediate ITGB2 expression and cell invasion. Consistently, ITGB2 and PRDM4 mRNA levels are significantly increased in metastatic prostate cancer. In addition, PRDM4 contributes to YAP‐induced tumorigenesis possibly via mediating the expression of other YAP target genes. Our results demonstrate that YAP promotes cell invasion by inducing leukocyte‐specific integrin expression, and identify PRDM4 as a novel transcription factor for YAP targets. Synopsis Yes‐associated protein (YAP) is a transcriptional co‐activator and major effector of the Hippo pathway, promoting cell proliferation and stemness. YAP interacts with PRDM4, thereby promoting transendothelial invasion of cancer cells by inducing expression of the leukocyte‐specific integrin ITGB2. PR/SET domain 4 (PRDM4) interacts with YAP to promote transcriptional activation of target genes. PRDM4 and TEAD co‐ordinately mediate the activation of the YAP target gene ITGB2. YAP‐induced ITGB2 expression promotes cancer cell invasion in a manner mimicking leukocytes. Graphical Abstract Yes‐associated protein (YAP) is a transcriptional co‐activator and major effector of the Hippo pathway, promoting cell proliferation and stemness. YAP interacts with PRDM4, thereby promoting transendothelial invasion of cancer cells by inducing expression of the leukocyte‐specific integrin ITGB2.
Yes‐associated protein (YAP) is a transcriptional co‐activator and a major effector of the Hippo pathway that promotes cell proliferation and stemness, while inhibiting apoptosis. YAP plays a central role in organ size control, and its deregulation strongly promotes cancer initiation and progression. However, the mechanisms by which YAP promotes cell invasion and metastasis are not fully understood. Here, we report that YAP induces leukocyte‐specific integrin β2 (ITGB2) expression in cancer cells, thereby promoting cell invasion through the endothelium in a manner mimicking leukocytes. Through independent biochemical purification and a functional screen, we further identified PR/SET domain 4 (PRDM4) as a transcription factor interacting with the WW domains of YAP to mediate ITGB2 expression and cell invasion. Consistently, ITGB2 and PRDM4 mRNA levels are significantly increased in metastatic prostate cancer. In addition, PRDM4 contributes to YAP‐induced tumorigenesis possibly via mediating the expression of other YAP target genes. Our results demonstrate that YAP promotes cell invasion by inducing leukocyte‐specific integrin expression, and identify PRDM4 as a novel transcription factor for YAP targets. Synopsis Yes‐associated protein (YAP) is a transcriptional co‐activator and major effector of the Hippo pathway, promoting cell proliferation and stemness. YAP interacts with PRDM4, thereby promoting transendothelial invasion of cancer cells by inducing expression of the leukocyte‐specific integrin ITGB2. PR/SET domain 4 (PRDM4) interacts with YAP to promote transcriptional activation of target genes. PRDM4 and TEAD co‐ordinately mediate the activation of the YAP target gene ITGB2. YAP‐induced ITGB2 expression promotes cancer cell invasion in a manner mimicking leukocytes. Yes‐associated protein (YAP) is a transcriptional co‐activator and major effector of the Hippo pathway, promoting cell proliferation and stemness. YAP interacts with PRDM4, thereby promoting transendothelial invasion of cancer cells by inducing expression of the leukocyte‐specific integrin ITGB2.
Yes-associated protein (YAP) is a transcriptional co-activator and a major effector of the Hippo pathway that promotes cell proliferation and stemness, while inhibiting apoptosis. YAP plays a central role in organ size control, and its deregulation strongly promotes cancer initiation and progression. However, the mechanisms by which YAP promotes cell invasion and metastasis are not fully understood. Here, we report that YAP induces leukocyte-specific integrin β2 (ITGB2) expression in cancer cells, thereby promoting cell invasion through the endothelium in a manner mimicking leukocytes. Through independent biochemical purification and a functional screen, we further identified PR/SET domain 4 (PRDM4) as a transcription factor interacting with the WW domains of YAP to mediate ITGB2 expression and cell invasion. Consistently, ITGB2 and PRDM4 mRNA levels are significantly increased in metastatic prostate cancer. In addition, PRDM4 contributes to YAP-induced tumorigenesis possibly via mediating the expression of other YAP target genes. Our results demonstrate that YAP promotes cell invasion by inducing leukocyte-specific integrin expression, and identify PRDM4 as a novel transcription factor for YAP targets.Yes-associated protein (YAP) is a transcriptional co-activator and a major effector of the Hippo pathway that promotes cell proliferation and stemness, while inhibiting apoptosis. YAP plays a central role in organ size control, and its deregulation strongly promotes cancer initiation and progression. However, the mechanisms by which YAP promotes cell invasion and metastasis are not fully understood. Here, we report that YAP induces leukocyte-specific integrin β2 (ITGB2) expression in cancer cells, thereby promoting cell invasion through the endothelium in a manner mimicking leukocytes. Through independent biochemical purification and a functional screen, we further identified PR/SET domain 4 (PRDM4) as a transcription factor interacting with the WW domains of YAP to mediate ITGB2 expression and cell invasion. Consistently, ITGB2 and PRDM4 mRNA levels are significantly increased in metastatic prostate cancer. In addition, PRDM4 contributes to YAP-induced tumorigenesis possibly via mediating the expression of other YAP target genes. Our results demonstrate that YAP promotes cell invasion by inducing leukocyte-specific integrin expression, and identify PRDM4 as a novel transcription factor for YAP targets.
Yes-associated protein (YAP) is a transcriptional co-activator and a major effector of the Hippo pathway that promotes cell proliferation and stemness, while inhibiting apoptosis. YAP plays a central role in organ size control, and its deregulation strongly promotes cancer initiation and progression. However, the mechanisms by which YAP promotes cell invasion and metastasis are not fully understood. Here, we report that YAP induces leukocyte-specific ( ) expression in cancer cells, thereby promoting cell invasion through the endothelium in a manner mimicking leukocytes. Through independent biochemical purification and a functional screen, we further identified PR/SET domain 4 (PRDM4) as a transcription factor interacting with the WW domains of YAP to mediate expression and cell invasion. Consistently, and mRNA levels are significantly increased in metastatic prostate cancer. In addition, PRDM4 contributes to YAP-induced tumorigenesis possibly via mediating the expression of other YAP target genes. Our results demonstrate that YAP promotes cell invasion by inducing leukocyte-specific integrin expression, and identify PRDM4 as a novel transcription factor for YAP targets.
Yes‐associated protein ( YAP ) is a transcriptional co‐activator and a major effector of the Hippo pathway that promotes cell proliferation and stemness, while inhibiting apoptosis. YAP plays a central role in organ size control, and its deregulation strongly promotes cancer initiation and progression. However, the mechanisms by which YAP promotes cell invasion and metastasis are not fully understood. Here, we report that YAP induces leukocyte‐specific integrin β2 ( ITGB 2 ) expression in cancer cells, thereby promoting cell invasion through the endothelium in a manner mimicking leukocytes. Through independent biochemical purification and a functional screen, we further identified PR / SET domain 4 ( PRDM 4) as a transcription factor interacting with the WW domains of YAP to mediate ITGB 2 expression and cell invasion. Consistently, ITGB 2 and PRDM 4 mRNA levels are significantly increased in metastatic prostate cancer. In addition, PRDM 4 contributes to YAP ‐induced tumorigenesis possibly via mediating the expression of other YAP target genes. Our results demonstrate that YAP promotes cell invasion by inducing leukocyte‐specific integrin expression, and identify PRDM 4 as a novel transcription factor for YAP targets.
Author Si, Yuan
Li, Li
Feng, Xin‐Hua
Liu, Huan
Zhang, Haitao
Shen, Shuying
Zhao, Jonathan C
Cao, Xiaolei
Yan, Huan
Ji, Xinyan
Zhang, Hailong
Dai, Xiaoming
Yu, Jindan
Zhao, Bin
Chen, Jianfeng
AuthorAffiliation 1 Life Sciences Institute and Innovation Center for Cell Signaling Network Zhejiang University Hangzhou Zhejiang China
2 State Key Laboratory of Cell Biology CAS Center for Excellence in Molecular Cell Science Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai China
3 Institute of Aging Research Hangzhou Normal University Hangzhou Zhejiang China
4 Department of Medicine‐Hematology/Oncology Robert H. Lurie Comprehensive Cancer Center Northwestern University Feinberg School of Medicine Chicago IL USA
AuthorAffiliation_xml – name: 2 State Key Laboratory of Cell Biology CAS Center for Excellence in Molecular Cell Science Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai China
– name: 4 Department of Medicine‐Hematology/Oncology Robert H. Lurie Comprehensive Cancer Center Northwestern University Feinberg School of Medicine Chicago IL USA
– name: 3 Institute of Aging Research Hangzhou Normal University Hangzhou Zhejiang China
– name: 1 Life Sciences Institute and Innovation Center for Cell Signaling Network Zhejiang University Hangzhou Zhejiang China
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Issue 6
Keywords Hippo pathway
yes‐associated protein
cell invasion
PRDM4
ITGB2
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References Prensner, Iyer, Balbin, Dhanasekaran, Cao, Brenner, Laxman, Asangani, Grasso, Kominsky (CR37) 2011; 29
Tan (CR26) 2012; 32
Atkins, Potier, Romanelli, Jacobs, Mach, Hamaratoglu, Aerts, Halder (CR21) 2016; 26
Cao, Pfaff, Gage (CR60) 2008; 22
Psaila, Lyden (CR44) 2009; 9
Dong, Feldmann, Huang, Wu, Zhang, Comerford, Gayyed, Anders, Maitra, Pan (CR16) 2007; 130
Wu, Mathioudakis, Diagouraga, Dong, Dombrovski, Baudat, Cusack, de Massy, Kadlec (CR35) 2013; 5
Alarcon, Zaromytidou, Xi, Gao, Yu, Fujisawa, Barlas, Miller, Manova‐Todorova, Macias (CR52) 2009; 139
Bora‐Singhal, Nguyen, Schaal, Perumal, Singh, Coppola, Chellappan (CR53) 2015; 33
Strano, Munarriz, Rossi, Castagnoli, Shaul, Sacchi, Oren, Sudol, Cesareni, Blandino (CR48) 2001; 276
Hao, Chun, Cheung, Rashidi, Yang (CR5) 2008; 283
Feng, Degese, Iglesias‐Bartolome, Vaque, Molinolo, Rodrigues, Zaidi, Ksander, Merlino, Sodhi (CR11) 2014; 25
Camargo, Gokhale, Johnnidis, Fu, Bell, Jaenisch, Brummelkamp (CR15) 2007; 17
Zhao, Wei, Li, Udan, Yang, Kim, Xie, Ikenoue, Yu, Li (CR3) 2007; 21
Zender, Spector, Xue, Flemming, Cordon‐Cardo, Silke, Fan, Luk, Wigler, Hannon (CR12) 2006; 125
Drbal, Angelisova, Hilgert, Cerny, Novak, Horejsi (CR65) 2001; 98
Omerovic, Puggioni, Napoletano, Visco, Fraioli, Frati, Gulino, Alimandi (CR49) 2004; 294
Lei, Zhang, Zhao, Zha, Bai, Pei, Zhao, Xiong, Guan (CR6) 2008; 28
Yu, Zhao, Guan (CR2) 2015; 163
Zhou, Conrad, Xia, Park, Payer, Yin, Lauwers, Thasler, Lee, Avruch (CR20) 2009; 16
Qiao, Chen, Lim, Finch‐Edmondson, Seshachalam, Qin, Jiang, Low, Singh, Lim (CR24) 2017; 19
Zhao, Li, Lu, Wang, Liu, Lei, Guan (CR45) 2011; 25
Pan (CR1) 2010; 19
Iyer, Niknafs, Malik, Singhal, Sahu, Hosono, Barrette, Prensner, Evans, Zhao (CR38) 2015; 47
Hohenauer, Moore (CR34) 2012; 139
Dhananjayan, Ramamoorthy, Khan, Ismail, Sun, Slingerland, O'Malley, Nawaz (CR54) 2006; 20
Zhao, Li, Tumaneng, Wang, Guan (CR4) 2010; 24
Komuro, Nagai, Navin, Sudol (CR50) 2003; 278
Song, Mak, Topol, Yun, Hu, Garrett, Chen, Park, Chang, Simpson (CR19) 2010; 107
Zhao, Kim, Ye, Lai, Guan (CR28) 2009; 69
Wang, Huang, Chen (CR46) 2011; 286
Chittka, Nitarska, Grazini, Richardson (CR58) 2012; 287
Lee, Lee, Kim, Kim, Park, Byun, Kim, Jeong, Calvisi, Kim (CR14) 2010; 107
Reymond, d'Agua, Ridley (CR33) 2013; 13
Zhi, Zhao, Zhou, Liu, Chen (CR51) 2012; 180
Lian, Kim, Okazawa, Zhao, Zhao, Yu, Chinnaiyan, Israel, Goldstein, Abujarour (CR59) 2010; 24
Overholtzer, Zhang, Smolen, Muir, Li, Sgroi, Deng, Brugge, Haber (CR23) 2006; 103
Asaoka, Hata, Namae, Furutani‐Seiki, Nishina (CR57) 2014; 9
Grossman, Heath, Ferretti, Varmus, Lowy, Kibbe, Staudt (CR67) 2016; 375
Qing, Yin, Wang, Zheng, Guo, Schozer, Deng, Pan (CR55) 2014; 3
Schlegelmilch, Mohseni, Kirak, Pruszak, Rodriguez, Zhou, Kreger, Vasioukhin, Avruch, Brummelkamp (CR18) 2011; 144
Morin‐Kensicki, Boone, Howell, Stonebraker, Teed, Alb, Magnuson, O'Neal, Milgram (CR61) 2006; 26
Zhao, Ye, Yu, Li, Li, Li, Lin, Wang, Chinnaiyan, Lai (CR22) 2008; 22
Beltran, Rickman, Park, Chae, Sboner, MacDonald, Wang, Sheikh, Terry, Tagawa (CR40) 2011; 1
Moroishi, Hansen, Guan (CR13) 2015; 15
Hiratsuka, Watanabe, Aburatani, Maru (CR43) 2006; 8
Enzo, Santinon, Pocaterra, Aragona, Bresolin, Forcato, Grifoni, Pession, Zanconato, Guzzo (CR41) 2015; 34
Uhlen, Zhang, Lee, Sjostedt, Fagerberg, Bidkhori, Benfeitas, Arif, Liu, Edfors (CR63) 2017; 357
Tapon, Harvey, Bell, Wahrer, Schiripo, Haber, Hariharan (CR29) 2002; 110
Oh, Slattery, Ma, White, Mann, Irvine (CR56) 2014; 8
Oka, Mazack, Sudol (CR7) 2008; 283
Robinson, Van Allen, Wu, Schultz, Lonigro, Mosquera, Montgomery, Taplin, Pritchard, Attard (CR39) 2015; 161
Zhang, Chen (CR32) 2012; 6
Yagi, Chen, Shigesada, Murakami, Ito (CR47) 1999; 18
Shaw, Ma, Kim, Rao, Hartman, Froio, Yang, Jones, Liu, Nusrat (CR31) 2004; 200
Yu, Luo, Mo, Liu, Kim, Meng, Zhao, Peyman, Ouyang, Jiang (CR10) 2014; 25
Lu, Li, Kim, Bossuyt, Liu, Qiu, Wang, Halder, Finegold, Lee (CR17) 2010; 107
Bogani, Morgan, Nelson, Costello, McGouran, Kessler, Robertson, Bikoff (CR42) 2013; 33
Muller (CR30) 2011; 6
Zhang, Bai, David, Dong, Zheng, Cai, Giovannini, Liu, Anders, Pan (CR9) 2010; 19
Zhao, Li, Wang, Wang, Yu, Guan (CR25) 2012; 26
Huang, Wu, Barrera, Matthews, Pan (CR8) 2005; 122
Yan, Xiong, Xu, Li, Cheng, Chen, Ding, Xu, Zheng (CR62) 2012; 41
Chan, Lim, Huang, Chong, Gunaratne, Hogue, Blackstock, Harvey, Hong (CR27) 2011; 30
Sudol, Shields, Farooq (CR64) 2012; 23
Chen, Yang, Kim, Carman, Springer (CR66) 2006; 103
(CR36) 2015; 163
2004; 200
2015; 34
2012; 287
2010; 107
2010; 19
2002; 110
2015; 33
2014; 25
2013; 5
2003; 278
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2008; 283
2009; 139
2001; 276
2013; 33
2005; 122
2009; 9
2016; 375
2017; 19
2012; 6
2016; 26
2011; 144
2006; 103
2012; 41
References_xml – volume: 22
  start-page: 1962
  year: 2008
  end-page: 1971
  ident: CR22
  article-title: TEAD mediates YAP‐dependent gene induction and growth control
  publication-title: Genes Dev
– volume: 103
  start-page: 13062
  year: 2006
  end-page: 13067
  ident: CR66
  article-title: Regulation of outside‐in signaling and affinity by the beta2 I domain of integrin alphaLbeta2
  publication-title: Proc Natl Acad Sci USA
– volume: 47
  start-page: 199
  year: 2015
  end-page: 208
  ident: CR38
  article-title: The landscape of long noncoding RNAs in the human transcriptome
  publication-title: Nat Genet
– volume: 22
  start-page: 3320
  year: 2008
  end-page: 3334
  ident: CR60
  article-title: YAP regulates neural progenitor cell number via the TEA domain transcription factor
  publication-title: Genes Dev
– volume: 21
  start-page: 2747
  year: 2007
  end-page: 2761
  ident: CR3
  article-title: Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control
  publication-title: Genes Dev
– volume: 294
  start-page: 469
  year: 2004
  end-page: 479
  ident: CR49
  article-title: Ligand‐regulated association of ErbB‐4 to the transcriptional co‐activator YAP65 controls transcription at the nuclear level
  publication-title: Exp Cell Res
– volume: 30
  start-page: 600
  year: 2011
  end-page: 610
  ident: CR27
  article-title: WW domain‐mediated interaction with Wbp2 is important for the oncogenic property of TAZ
  publication-title: Oncogene
– volume: 26
  start-page: 54
  year: 2012
  end-page: 68
  ident: CR25
  article-title: Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis
  publication-title: Genes Dev
– volume: 13
  start-page: 858
  year: 2013
  end-page: 870
  ident: CR33
  article-title: Crossing the endothelial barrier during metastasis
  publication-title: Nat Rev Cancer
– volume: 125
  start-page: 1253
  year: 2006
  end-page: 1267
  ident: CR12
  article-title: Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach
  publication-title: Cell
– volume: 6
  start-page: 323
  year: 2011
  end-page: 344
  ident: CR30
  article-title: Mechanisms of leukocyte transendothelial migration
  publication-title: Annu Rev Pathol
– volume: 3
  start-page: e02564
  year: 2014
  ident: CR55
  article-title: The Hippo effector Yorkie activates transcription by interacting with a histone methyltransferase complex through Ncoa6
  publication-title: Elife
– volume: 103
  start-page: 12405
  year: 2006
  end-page: 12410
  ident: CR23
  article-title: Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon
  publication-title: Proc Natl Acad Sci USA
– volume: 163
  start-page: 811
  year: 2015
  end-page: 828
  ident: CR2
  article-title: Hippo pathway in organ size control, tissue homeostasis, and cancer
  publication-title: Cell
– volume: 29
  start-page: 742
  year: 2011
  end-page: 749
  ident: CR37
  article-title: Transcriptome sequencing across a prostate cancer cohort identifies PCAT‐1, an unannotated lincRNA implicated in disease progression
  publication-title: Nat Biotechnol
– volume: 107
  start-page: 1431
  year: 2010
  end-page: 1436
  ident: CR19
  article-title: Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression
  publication-title: Proc Natl Acad Sci USA
– volume: 278
  start-page: 33334
  year: 2003
  end-page: 33341
  ident: CR50
  article-title: WW domain‐containing protein YAP associates with ErbB‐4 and acts as a co‐transcriptional activator for the carboxyl‐terminal fragment of ErbB‐4 that translocates to the nucleus
  publication-title: J Biol Chem
– volume: 34
  start-page: 1349
  year: 2015
  end-page: 1370
  ident: CR41
  article-title: Aerobic glycolysis tunes YAP/TAZ transcriptional activity
  publication-title: EMBO J
– volume: 8
  start-page: 449
  year: 2014
  end-page: 459
  ident: CR56
  article-title: Yorkie promotes transcription by recruiting a histone methyltransferase complex
  publication-title: Cell Rep
– volume: 28
  start-page: 2426
  year: 2008
  end-page: 2436
  ident: CR6
  article-title: TAZ promotes cell proliferation and epithelial‐mesenchymal transition and is inhibited by the hippo pathway
  publication-title: Mol Cell Biol
– volume: 17
  start-page: 2054
  year: 2007
  end-page: 2060
  ident: CR15
  article-title: YAP1 increases organ size and expands undifferentiated progenitor cells
  publication-title: Curr Biol
– volume: 139
  start-page: 757
  year: 2009
  end-page: 769
  ident: CR52
  article-title: Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF‐beta pathways
  publication-title: Cell
– volume: 375
  start-page: 1109
  year: 2016
  end-page: 1112
  ident: CR67
  article-title: Toward a shared vision for cancer genomic data
  publication-title: N Engl J Med
– volume: 26
  start-page: 77
  year: 2006
  end-page: 87
  ident: CR61
  article-title: Defects in yolk sac vasculogenesis, chorioallantoic fusion, and embryonic axis elongation in mice with targeted disruption of Yap65
  publication-title: Mol Cell Biol
– volume: 69
  start-page: 1089
  year: 2009
  end-page: 1098
  ident: CR28
  article-title: Both TEAD‐binding and WW domains are required for the growth stimulation and oncogenic transformation activity of yes‐associated protein
  publication-title: Cancer Res
– volume: 180
  start-page: 2452
  year: 2012
  end-page: 2461
  ident: CR51
  article-title: YAP promotes breast cell proliferation and survival partially through stabilizing the KLF5 transcription factor
  publication-title: Am J Pathol
– volume: 144
  start-page: 782
  year: 2011
  end-page: 795
  ident: CR18
  article-title: Yap1 acts downstream of alpha‐catenin to control epidermal proliferation
  publication-title: Cell
– volume: 19
  start-page: 1495
  year: 2017
  end-page: 1502
  ident: CR24
  article-title: YAP regulates actin dynamics through ARHGAP29 and promotes metastasis
  publication-title: Cell Rep
– volume: 41
  start-page: 2166
  year: 2012
  end-page: 2174
  ident: CR62
  article-title: Identification of recurrence‐related genes by integrating microRNA and gene expression profiling of gastric cancer
  publication-title: Int J Oncol
– volume: 286
  start-page: 4364
  year: 2011
  end-page: 4370
  ident: CR46
  article-title: Angiomotin‐like proteins associate with and negatively regulate YAP1
  publication-title: J Biol Chem
– volume: 24
  start-page: 1106
  year: 2010
  end-page: 1118
  ident: CR59
  article-title: The role of YAP transcription coactivator in regulating stem cell self‐renewal and differentiation
  publication-title: Genes Dev
– volume: 98
  start-page: 1561
  year: 2001
  end-page: 1566
  ident: CR65
  article-title: A proteolytically truncated form of free CD18, the common chain of leukocyte integrins, as a novel marker of activated myeloid cells
  publication-title: Blood
– volume: 1
  start-page: 487
  year: 2011
  end-page: 495
  ident: CR40
  article-title: Molecular characterization of neuroendocrine prostate cancer and identification of new drug targets
  publication-title: Cancer Discov
– volume: 20
  start-page: 2343
  year: 2006
  end-page: 2354
  ident: CR54
  article-title: WW domain binding protein‐2, an E6‐associated protein interacting protein, acts as a coactivator of estrogen and progesterone receptors
  publication-title: Mol Endocrinol
– volume: 9
  start-page: 285
  year: 2009
  end-page: 293
  ident: CR44
  article-title: The metastatic niche: adapting the foreign soil
  publication-title: Nat Rev Cancer
– volume: 25
  start-page: 831
  year: 2014
  end-page: 845
  ident: CR11
  article-title: Hippo‐independent activation of YAP by the GNAQ uveal melanoma oncogene through a trio‐regulated rho GTPase signaling circuitry
  publication-title: Cancer Cell
– volume: 32
  start-page: 241
  year: 2012
  end-page: 269
  ident: CR26
  article-title: The leucocyte beta2 (CD18) integrins: the structure, functional regulation and signalling properties
  publication-title: Biosci Rep
– volume: 15
  start-page: 73
  year: 2015
  end-page: 79
  ident: CR13
  article-title: The emerging roles of YAP and TAZ in cancer
  publication-title: Nat Rev Cancer
– volume: 287
  start-page: 42995
  year: 2012
  end-page: 43006
  ident: CR58
  article-title: Transcription factor positive regulatory domain 4 (PRDM4) recruits protein arginine methyltransferase 5 (PRMT5) to mediate histone arginine methylation and control neural stem cell proliferation and differentiation
  publication-title: J Biol Chem
– volume: 19
  start-page: 27
  year: 2010
  end-page: 38
  ident: CR9
  article-title: The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals
  publication-title: Dev Cell
– volume: 25
  start-page: 822
  year: 2014
  end-page: 830
  ident: CR10
  article-title: Mutant Gq/11 promote uveal melanoma tumorigenesis by activating YAP
  publication-title: Cancer Cell
– volume: 24
  start-page: 72
  year: 2010
  end-page: 85
  ident: CR4
  article-title: A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta‐TRCP)
  publication-title: Genes Dev
– volume: 33
  start-page: 3936
  year: 2013
  end-page: 3950
  ident: CR42
  article-title: The PR/SET domain zinc finger protein Prdm4 regulates gene expression in embryonic stem cells but plays a nonessential role in the developing mouse embryo
  publication-title: Mol Cell Biol
– volume: 122
  start-page: 421
  year: 2005
  end-page: 434
  ident: CR8
  article-title: The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Homolog of YAP
  publication-title: Cell
– volume: 23
  start-page: 827
  year: 2012
  end-page: 833
  ident: CR64
  article-title: Structures of YAP protein domains reveal promising targets for development of new cancer drugs
  publication-title: Semin Cell Dev Biol
– volume: 139
  start-page: 2267
  year: 2012
  end-page: 2282
  ident: CR34
  article-title: The Prdm family: expanding roles in stem cells and development
  publication-title: Development
– volume: 161
  start-page: 1215
  year: 2015
  end-page: 1228
  ident: CR39
  article-title: Integrative clinical genomics of advanced prostate cancer
  publication-title: Cell
– volume: 26
  start-page: 2101
  year: 2016
  end-page: 2113
  ident: CR21
  article-title: An ectopic network of transcription factors regulated by hippo signaling drives growth and invasion of a malignant tumor model
  publication-title: Curr Biol
– volume: 107
  start-page: 8248
  year: 2010
  end-page: 8253
  ident: CR14
  article-title: The Hippo‐Salvador pathway restrains hepatic oval cell proliferation, liver size, and liver tumorigenesis
  publication-title: Proc Natl Acad Sci USA
– volume: 276
  start-page: 15164
  year: 2001
  end-page: 15173
  ident: CR48
  article-title: Physical interaction with Yes‐associated protein enhances p73 transcriptional activity
  publication-title: J Biol Chem
– volume: 6
  start-page: 20
  year: 2012
  end-page: 29
  ident: CR32
  article-title: The regulation of integrin function by divalent cations
  publication-title: Cell Adh Migr
– volume: 16
  start-page: 425
  year: 2009
  end-page: 438
  ident: CR20
  article-title: Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene
  publication-title: Cancer Cell
– volume: 163
  start-page: 1011
  year: 2015
  end-page: 1025
  ident: CR36
  article-title: The molecular taxonomy of primary prostate cancer
  publication-title: Cell
– volume: 130
  start-page: 1120
  year: 2007
  end-page: 1133
  ident: CR16
  article-title: Elucidation of a universal size‐control mechanism in and mammals
  publication-title: Cell
– volume: 25
  start-page: 51
  year: 2011
  end-page: 63
  ident: CR45
  article-title: Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein
  publication-title: Genes Dev
– volume: 107
  start-page: 1437
  year: 2010
  end-page: 1442
  ident: CR17
  article-title: Hippo signaling is a potent growth and tumor suppressor pathway in the mammalian liver
  publication-title: Proc Natl Acad Sci USA
– volume: 18
  start-page: 2551
  year: 1999
  end-page: 2562
  ident: CR47
  article-title: A WW domain‐containing yes‐associated protein (YAP) is a novel transcriptional co‐activator
  publication-title: EMBO J
– volume: 9
  start-page: e97365
  year: 2014
  ident: CR57
  article-title: The Hippo pathway controls a switch between retinal progenitor cell proliferation and photoreceptor cell differentiation in zebrafish
  publication-title: PLoS One
– volume: 8
  start-page: 1369
  year: 2006
  end-page: 1375
  ident: CR43
  article-title: Tumour‐mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis
  publication-title: Nat Cell Biol
– volume: 110
  start-page: 467
  year: 2002
  end-page: 478
  ident: CR29
  article-title: salvador Promotes both cell cycle exit and apoptosis in and is mutated in human cancer cell lines
  publication-title: Cell
– volume: 5
  start-page: 13
  year: 2013
  end-page: 20
  ident: CR35
  article-title: Molecular basis for the regulation of the H3K4 methyltransferase activity of PRDM9
  publication-title: Cell Rep
– volume: 33
  start-page: 1705
  year: 2015
  end-page: 1718
  ident: CR53
  article-title: YAP1 regulates OCT4 activity and SOX2 expression to facilitate self‐renewal and vascular mimicry of stem‐like cells
  publication-title: Stem Cells
– volume: 357
  start-page: eaan2507
  year: 2017
  ident: CR63
  article-title: A pathology atlas of the human cancer transcriptome
  publication-title: Science
– volume: 19
  start-page: 491
  year: 2010
  end-page: 505
  ident: CR1
  article-title: The hippo signaling pathway in development and cancer
  publication-title: Dev Cell
– volume: 200
  start-page: 1571
  year: 2004
  end-page: 1580
  ident: CR31
  article-title: Coordinated redistribution of leukocyte LFA‐1 and endothelial cell ICAM‐1 accompany neutrophil transmigration
  publication-title: J Exp Med
– volume: 283
  start-page: 27534
  year: 2008
  end-page: 27546
  ident: CR7
  article-title: Mst2 and Lats kinases regulate apoptotic function of Yes kinase‐associated protein (YAP)
  publication-title: J Biol Chem
– volume: 283
  start-page: 5496
  year: 2008
  end-page: 5509
  ident: CR5
  article-title: Tumor suppressor LATS1 is a negative regulator of oncogene YAP
  publication-title: J Biol Chem
– volume: 22
  start-page: 1962
  year: 2008
  end-page: 1971
  article-title: TEAD mediates YAP‐dependent gene induction and growth control
  publication-title: Genes Dev
– volume: 18
  start-page: 2551
  year: 1999
  end-page: 2562
  article-title: A WW domain‐containing yes‐associated protein (YAP) is a novel transcriptional co‐activator
  publication-title: EMBO J
– volume: 130
  start-page: 1120
  year: 2007
  end-page: 1133
  article-title: Elucidation of a universal size‐control mechanism in and mammals
  publication-title: Cell
– volume: 107
  start-page: 1437
  year: 2010
  end-page: 1442
  article-title: Hippo signaling is a potent growth and tumor suppressor pathway in the mammalian liver
  publication-title: Proc Natl Acad Sci USA
– volume: 6
  start-page: 20
  year: 2012
  end-page: 29
  article-title: The regulation of integrin function by divalent cations
  publication-title: Cell Adh Migr
– volume: 19
  start-page: 27
  year: 2010
  end-page: 38
  article-title: The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals
  publication-title: Dev Cell
– volume: 41
  start-page: 2166
  year: 2012
  end-page: 2174
  article-title: Identification of recurrence‐related genes by integrating microRNA and gene expression profiling of gastric cancer
  publication-title: Int J Oncol
– volume: 34
  start-page: 1349
  year: 2015
  end-page: 1370
  article-title: Aerobic glycolysis tunes YAP/TAZ transcriptional activity
  publication-title: EMBO J
– volume: 180
  start-page: 2452
  year: 2012
  end-page: 2461
  article-title: YAP promotes breast cell proliferation and survival partially through stabilizing the KLF5 transcription factor
  publication-title: Am J Pathol
– volume: 200
  start-page: 1571
  year: 2004
  end-page: 1580
  article-title: Coordinated redistribution of leukocyte LFA‐1 and endothelial cell ICAM‐1 accompany neutrophil transmigration
  publication-title: J Exp Med
– volume: 21
  start-page: 2747
  year: 2007
  end-page: 2761
  article-title: Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control
  publication-title: Genes Dev
– volume: 139
  start-page: 757
  year: 2009
  end-page: 769
  article-title: Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF‐beta pathways
  publication-title: Cell
– volume: 9
  start-page: e97365
  year: 2014
  article-title: The Hippo pathway controls a switch between retinal progenitor cell proliferation and photoreceptor cell differentiation in zebrafish
  publication-title: PLoS One
– volume: 19
  start-page: 491
  year: 2010
  end-page: 505
  article-title: The hippo signaling pathway in development and cancer
  publication-title: Dev Cell
– volume: 13
  start-page: 858
  year: 2013
  end-page: 870
  article-title: Crossing the endothelial barrier during metastasis
  publication-title: Nat Rev Cancer
– volume: 276
  start-page: 15164
  year: 2001
  end-page: 15173
  article-title: Physical interaction with Yes‐associated protein enhances p73 transcriptional activity
  publication-title: J Biol Chem
– volume: 8
  start-page: 449
  year: 2014
  end-page: 459
  article-title: Yorkie promotes transcription by recruiting a histone methyltransferase complex
  publication-title: Cell Rep
– volume: 25
  start-page: 51
  year: 2011
  end-page: 63
  article-title: Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein
  publication-title: Genes Dev
– volume: 163
  start-page: 1011
  year: 2015
  end-page: 1025
  article-title: The molecular taxonomy of primary prostate cancer
  publication-title: Cell
– volume: 3
  start-page: e02564
  year: 2014
  article-title: The Hippo effector Yorkie activates transcription by interacting with a histone methyltransferase complex through Ncoa6
  publication-title: Elife
– volume: 283
  start-page: 5496
  year: 2008
  end-page: 5509
  article-title: Tumor suppressor LATS1 is a negative regulator of oncogene YAP
  publication-title: J Biol Chem
– volume: 47
  start-page: 199
  year: 2015
  end-page: 208
  article-title: The landscape of long noncoding RNAs in the human transcriptome
  publication-title: Nat Genet
– volume: 17
  start-page: 2054
  year: 2007
  end-page: 2060
  article-title: YAP1 increases organ size and expands undifferentiated progenitor cells
  publication-title: Curr Biol
– volume: 16
  start-page: 425
  year: 2009
  end-page: 438
  article-title: Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene
  publication-title: Cancer Cell
– volume: 25
  start-page: 831
  year: 2014
  end-page: 845
  article-title: Hippo‐independent activation of YAP by the GNAQ uveal melanoma oncogene through a trio‐regulated rho GTPase signaling circuitry
  publication-title: Cancer Cell
– volume: 19
  start-page: 1495
  year: 2017
  end-page: 1502
  article-title: YAP regulates actin dynamics through ARHGAP29 and promotes metastasis
  publication-title: Cell Rep
– volume: 278
  start-page: 33334
  year: 2003
  end-page: 33341
  article-title: WW domain‐containing protein YAP associates with ErbB‐4 and acts as a co‐transcriptional activator for the carboxyl‐terminal fragment of ErbB‐4 that translocates to the nucleus
  publication-title: J Biol Chem
– volume: 8
  start-page: 1369
  year: 2006
  end-page: 1375
  article-title: Tumour‐mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis
  publication-title: Nat Cell Biol
– volume: 98
  start-page: 1561
  year: 2001
  end-page: 1566
  article-title: A proteolytically truncated form of free CD18, the common chain of leukocyte integrins, as a novel marker of activated myeloid cells
  publication-title: Blood
– volume: 1
  start-page: 487
  year: 2011
  end-page: 495
  article-title: Molecular characterization of neuroendocrine prostate cancer and identification of new drug targets
  publication-title: Cancer Discov
– volume: 23
  start-page: 827
  year: 2012
  end-page: 833
  article-title: Structures of YAP protein domains reveal promising targets for development of new cancer drugs
  publication-title: Semin Cell Dev Biol
– volume: 9
  start-page: 285
  year: 2009
  end-page: 293
  article-title: The metastatic niche: adapting the foreign soil
  publication-title: Nat Rev Cancer
– volume: 28
  start-page: 2426
  year: 2008
  end-page: 2436
  article-title: TAZ promotes cell proliferation and epithelial‐mesenchymal transition and is inhibited by the hippo pathway
  publication-title: Mol Cell Biol
– volume: 144
  start-page: 782
  year: 2011
  end-page: 795
  article-title: Yap1 acts downstream of alpha‐catenin to control epidermal proliferation
  publication-title: Cell
– volume: 69
  start-page: 1089
  year: 2009
  end-page: 1098
  article-title: Both TEAD‐binding and WW domains are required for the growth stimulation and oncogenic transformation activity of yes‐associated protein
  publication-title: Cancer Res
– volume: 6
  start-page: 323
  year: 2011
  end-page: 344
  article-title: Mechanisms of leukocyte transendothelial migration
  publication-title: Annu Rev Pathol
– volume: 110
  start-page: 467
  year: 2002
  end-page: 478
  article-title: salvador Promotes both cell cycle exit and apoptosis in and is mutated in human cancer cell lines
  publication-title: Cell
– volume: 26
  start-page: 54
  year: 2012
  end-page: 68
  article-title: Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis
  publication-title: Genes Dev
– volume: 5
  start-page: 13
  year: 2013
  end-page: 20
  article-title: Molecular basis for the regulation of the H3K4 methyltransferase activity of PRDM9
  publication-title: Cell Rep
– volume: 20
  start-page: 2343
  year: 2006
  end-page: 2354
  article-title: WW domain binding protein‐2, an E6‐associated protein interacting protein, acts as a coactivator of estrogen and progesterone receptors
  publication-title: Mol Endocrinol
– volume: 283
  start-page: 27534
  year: 2008
  end-page: 27546
  article-title: Mst2 and Lats kinases regulate apoptotic function of Yes kinase‐associated protein (YAP)
  publication-title: J Biol Chem
– volume: 139
  start-page: 2267
  year: 2012
  end-page: 2282
  article-title: The Prdm family: expanding roles in stem cells and development
  publication-title: Development
– volume: 161
  start-page: 1215
  year: 2015
  end-page: 1228
  article-title: Integrative clinical genomics of advanced prostate cancer
  publication-title: Cell
– volume: 26
  start-page: 2101
  year: 2016
  end-page: 2113
  article-title: An ectopic network of transcription factors regulated by hippo signaling drives growth and invasion of a malignant tumor model
  publication-title: Curr Biol
– volume: 24
  start-page: 72
  year: 2010
  end-page: 85
  article-title: A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta‐TRCP)
  publication-title: Genes Dev
– volume: 163
  start-page: 811
  year: 2015
  end-page: 828
  article-title: Hippo pathway in organ size control, tissue homeostasis, and cancer
  publication-title: Cell
– volume: 357
  start-page: eaan2507
  year: 2017
  article-title: A pathology atlas of the human cancer transcriptome
  publication-title: Science
– volume: 122
  start-page: 421
  year: 2005
  end-page: 434
  article-title: The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Homolog of YAP
  publication-title: Cell
– volume: 107
  start-page: 8248
  year: 2010
  end-page: 8253
  article-title: The Hippo‐Salvador pathway restrains hepatic oval cell proliferation, liver size, and liver tumorigenesis
  publication-title: Proc Natl Acad Sci USA
– volume: 22
  start-page: 3320
  year: 2008
  end-page: 3334
  article-title: YAP regulates neural progenitor cell number via the TEA domain transcription factor
  publication-title: Genes Dev
– volume: 32
  start-page: 241
  year: 2012
  end-page: 269
  article-title: The leucocyte beta2 (CD18) integrins: the structure, functional regulation and signalling properties
  publication-title: Biosci Rep
– volume: 33
  start-page: 1705
  year: 2015
  end-page: 1718
  article-title: YAP1 regulates OCT4 activity and SOX2 expression to facilitate self‐renewal and vascular mimicry of stem‐like cells
  publication-title: Stem Cells
– volume: 103
  start-page: 12405
  year: 2006
  end-page: 12410
  article-title: Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon
  publication-title: Proc Natl Acad Sci USA
– volume: 24
  start-page: 1106
  year: 2010
  end-page: 1118
  article-title: The role of YAP transcription coactivator in regulating stem cell self‐renewal and differentiation
  publication-title: Genes Dev
– volume: 26
  start-page: 77
  year: 2006
  end-page: 87
  article-title: Defects in yolk sac vasculogenesis, chorioallantoic fusion, and embryonic axis elongation in mice with targeted disruption of Yap65
  publication-title: Mol Cell Biol
– volume: 125
  start-page: 1253
  year: 2006
  end-page: 1267
  article-title: Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach
  publication-title: Cell
– volume: 30
  start-page: 600
  year: 2011
  end-page: 610
  article-title: WW domain‐mediated interaction with Wbp2 is important for the oncogenic property of TAZ
  publication-title: Oncogene
– volume: 375
  start-page: 1109
  year: 2016
  end-page: 1112
  article-title: Toward a shared vision for cancer genomic data
  publication-title: N Engl J Med
– volume: 287
  start-page: 42995
  year: 2012
  end-page: 43006
  article-title: Transcription factor positive regulatory domain 4 (PRDM4) recruits protein arginine methyltransferase 5 (PRMT5) to mediate histone arginine methylation and control neural stem cell proliferation and differentiation
  publication-title: J Biol Chem
– volume: 107
  start-page: 1431
  year: 2010
  end-page: 1436
  article-title: Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression
  publication-title: Proc Natl Acad Sci USA
– volume: 15
  start-page: 73
  year: 2015
  end-page: 79
  article-title: The emerging roles of YAP and TAZ in cancer
  publication-title: Nat Rev Cancer
– volume: 25
  start-page: 822
  year: 2014
  end-page: 830
  article-title: Mutant Gq/11 promote uveal melanoma tumorigenesis by activating YAP
  publication-title: Cancer Cell
– volume: 103
  start-page: 13062
  year: 2006
  end-page: 13067
  article-title: Regulation of outside‐in signaling and affinity by the beta2 I domain of integrin alphaLbeta2
  publication-title: Proc Natl Acad Sci USA
– volume: 29
  start-page: 742
  year: 2011
  end-page: 749
  article-title: Transcriptome sequencing across a prostate cancer cohort identifies PCAT‐1, an unannotated lincRNA implicated in disease progression
  publication-title: Nat Biotechnol
– volume: 294
  start-page: 469
  year: 2004
  end-page: 479
  article-title: Ligand‐regulated association of ErbB‐4 to the transcriptional co‐activator YAP65 controls transcription at the nuclear level
  publication-title: Exp Cell Res
– volume: 33
  start-page: 3936
  year: 2013
  end-page: 3950
  article-title: The PR/SET domain zinc finger protein Prdm4 regulates gene expression in embryonic stem cells but plays a nonessential role in the developing mouse embryo
  publication-title: Mol Cell Biol
– volume: 286
  start-page: 4364
  year: 2011
  end-page: 4370
  article-title: Angiomotin‐like proteins associate with and negatively regulate YAP1
  publication-title: J Biol Chem
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Snippet Yes‐associated protein (YAP) is a transcriptional co‐activator and a major effector of the Hippo pathway that promotes cell proliferation and stemness, while...
Yes-associated protein (YAP) is a transcriptional co-activator and a major effector of the Hippo pathway that promotes cell proliferation and stemness, while...
Yes‐associated protein ( YAP ) is a transcriptional co‐activator and a major effector of the Hippo pathway that promotes cell proliferation and stemness, while...
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proquest
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wiley
springer
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Publisher
SubjectTerms Adaptor Proteins, Signal Transducing - genetics
Adaptor Proteins, Signal Transducing - physiology
Animals
Apoptosis
Cancer
CD18 Antigens - metabolism
Cell growth
cell invasion
Cell Line, Tumor
Cell proliferation
Cell Proliferation - genetics
Deregulation
DNA-Binding Proteins - genetics
DNA-Binding Proteins - metabolism
EMBO03
EMBO37
Endothelium
Gene expression
Genes
Hippo pathway
Humans
ITGB2
Kinases
Leukocytes
Male
Metastases
Mice
Mimicry
Neoplasm Invasiveness
Phosphoproteins - genetics
Phosphoproteins - physiology
PRDM4
Prostate cancer
Prostatic Neoplasms - metabolism
Prostatic Neoplasms - pathology
Proteins
Scientific Report
Scientific Reports
Transcription activation
Transcription factors
Transcription Factors - genetics
Transcription Factors - metabolism
Tumorigenesis
Yes-associated protein
Title PRDM4 mediates YAP‐induced cell invasion by activating leukocyte‐specific integrin β2 expression
URI https://link.springer.com/article/10.15252/embr.201745180
https://onlinelibrary.wiley.com/doi/abs/10.15252%2Fembr.201745180
https://www.ncbi.nlm.nih.gov/pubmed/29669796
https://www.proquest.com/docview/2051652646
https://www.proquest.com/docview/2027598116
https://pubmed.ncbi.nlm.nih.gov/PMC5989780
Volume 19
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