Transmembrane channel-like (TMC) genes are required for auditory and vestibular mechanosensation

• Published in: Pflügers Archiv Vol. 467; no. 1; pp. 85 - 94
• Main Authors: Kawashima, Yoshiyuki, Kurima, Kiyoto, Pan, Bifeng, Griffith, Andrew J., Holt, Jeffrey R.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.01.2015; Springer Nature B.V
• Subjects: Animals; Biomedical and Life Sciences; Biomedicine; Cell Biology; Hair Cells, Auditory - physiology; Hair Cells, Vestibular - physiology; Hearing - physiology; Human Physiology; Humans; Invited Review; Ion Channel Gating - physiology; Ion Channels - physiology; Mechanotransduction, Cellular - physiology; Molecular Medicine; Neurosciences; Postural Balance - physiology; Receptors; Mechanosensory; TMC1; Deafness; Hearing; Mechanoelectrical; Channel; Hair cell; Mechanotransduction; Transduction; TMC2

Mutations of the transmembrane channel-like 1 ( TMC1 ) gene can cause dominant and recessive forms of deafness in humans and mice. TMC1 is one of eight mammalian TMC genes of unknown function. The multi-pass transmembrane topologic structure of the proteins they encode suggests roles as a receptor,...