Transmembrane channel-like (TMC) genes are required for auditory and vestibular mechanosensation

Mutations of the transmembrane channel-like 1 ( TMC1 ) gene can cause dominant and recessive forms of deafness in humans and mice. TMC1 is one of eight mammalian TMC genes of unknown function. The multi-pass transmembrane topologic structure of the proteins they encode suggests roles as a receptor,...

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Published in	Pflügers Archiv Vol. 467; no. 1; pp. 85 - 94
Main Authors	Kawashima, Yoshiyuki, Kurima, Kiyoto, Pan, Bifeng, Griffith, Andrew J., Holt, Jeffrey R.
Format	Journal Article
Language	English
Published	Berlin/Heidelberg Springer Berlin Heidelberg 01.01.2015 Springer Nature B.V
Subjects	Animals Biomedical and Life Sciences Biomedicine Cell Biology Hair Cells, Auditory - physiology Hair Cells, Vestibular - physiology Hearing - physiology Human Physiology Humans Invited Review Ion Channel Gating - physiology Ion Channels - physiology Mechanotransduction, Cellular - physiology Molecular Medicine Neurosciences Postural Balance - physiology Receptors Mechanosensory TMC1 Deafness Hearing Mechanoelectrical Channel Hair cell Mechanotransduction Transduction TMC2
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Abstract	Mutations of the transmembrane channel-like 1 ( TMC1 ) gene can cause dominant and recessive forms of deafness in humans and mice. TMC1 is one of eight mammalian TMC genes of unknown function. The multi-pass transmembrane topologic structure of the proteins they encode suggests roles as a receptor, transporter, channel, or pump. Tmc1 and the closely related Tmc2 gene are expressed in neurosensory hair cells of the auditory and vestibular end organs of the mouse inner ear. Recent studies have demonstrated that Tmc1 and Tmc2 are specifically required for mechanoelectrical transduction in hair cells. The exact role of these proteins in mechanoelectrical transduction is unknown. TMC1 and TMC2 are viable candidates for the mechanoelectrical transduction channel of hair cells, whose component molecules have eluded identification for over 30 years. We expect that studies of TMC proteins will yield insights into molecular components and mechanisms of mechanosensation in auditory and vestibular hair cells, as well as in other tissues and organs.
AbstractList	Mutations of the transmembrane channel-like 1 (TMC1) gene can cause dominant and recessive forms of deafness in humans and mice. TMC1 is one of eight mammalian TMC genes of unknown function. The multi-pass transmembrane topologic structure of the proteins they encode suggests roles as a receptor, transporter, channel, or pump. Tmc1 and the closely related Tmc2 gene are expressed in neurosensory hair cells of the auditory and vestibular end organs of the mouse inner ear. Recent studies have demonstrated that Tmc1 and Tmc2 are specifically required for mechanoelectrical transduction in hair cells. The exact role of these proteins in mechanoelectrical transduction is unknown. TMC1 and TMC2 are viable candidates for the mechanoelectrical transduction channel of hair cells, whose component molecules have eluded identification for over 30 years. We expect that studies of TMC proteins will yield insights into molecular components and mechanisms of mechanosensation in auditory and vestibular hair cells, as well as in other tissues and organs.Mutations of the transmembrane channel-like 1 (TMC1) gene can cause dominant and recessive forms of deafness in humans and mice. TMC1 is one of eight mammalian TMC genes of unknown function. The multi-pass transmembrane topologic structure of the proteins they encode suggests roles as a receptor, transporter, channel, or pump. Tmc1 and the closely related Tmc2 gene are expressed in neurosensory hair cells of the auditory and vestibular end organs of the mouse inner ear. Recent studies have demonstrated that Tmc1 and Tmc2 are specifically required for mechanoelectrical transduction in hair cells. The exact role of these proteins in mechanoelectrical transduction is unknown. TMC1 and TMC2 are viable candidates for the mechanoelectrical transduction channel of hair cells, whose component molecules have eluded identification for over 30 years. We expect that studies of TMC proteins will yield insights into molecular components and mechanisms of mechanosensation in auditory and vestibular hair cells, as well as in other tissues and organs. Mutations of the transmembrane channel-like 1 (TMC1) gene can cause dominant and recessive forms of deafness in humans and mice. TMC1 is one of eight mammalian TMC genes of unknown function. The multi-pass transmembrane topologic structure of the proteins they encode suggests roles as a receptor, transporter, channel, or pump. Tmc1 and the closely related Tmc2 gene are expressed in neurosensory hair cells of the auditory and vestibular end organs of the mouse inner ear. Recent studies have demonstrated that Tmc1 and Tmc2 are specifically required for mechanoelectrical transduction in hair cells. The exact role of these proteins in mechanoelectrical transduction is unknown. TMC1 and TMC2 are viable candidates for the mechanoelectrical transduction channel of hair cells, whose component molecules have eluded identification for over 30 years. We expect that studies of TMC proteins will yield insights into molecular components and mechanisms of mechanosensation in auditory and vestibular hair cells, as well as in other tissues and organs. Issue Title: Physiological Aspects of Mechanosensing Mutations of the transmembrane channel-like 1 (TMC1) gene can cause dominant and recessive forms of deafness in humans and mice. TMC1 is one of eight mammalian TMC genes of unknown function. The multi-pass transmembrane topologic structure of the proteins they encode suggests roles as a receptor, transporter, channel, or pump. Tmc1 and the closely related Tmc2 gene are expressed in neurosensory hair cells of the auditory and vestibular end organs of the mouse inner ear. Recent studies have demonstrated that Tmc1 and Tmc2 are specifically required for mechanoelectrical transduction in hair cells. The exact role of these proteins in mechanoelectrical transduction is unknown. TMC1 and TMC2 are viable candidates for the mechanoelectrical transduction channel of hair cells, whose component molecules have eluded identification for over 30 years. We expect that studies of TMC proteins will yield insights into molecular components and mechanisms of mechanosensation in auditory and vestibular hair cells, as well as in other tissues and organs.[PUBLICATION ABSTRACT] Mutations of the transmembrane channel-like 1 ( TMC1 ) gene can cause dominant and recessive forms of deafness in humans and mice. TMC1 is one of eight mammalian TMC genes of unknown function. The multi-pass transmembrane topologic structure of the proteins they encode suggests roles as a receptor, transporter, channel or pump. Tmc1 and the closely related Tmc2 gene are expressed in neurosensory hair cells of the auditory and vestibular end organs of the mouse inner ear. Recent studies have demonstrated that Tmc1 and Tmc2 are specifically required for mechanoelectrical transduction in hair cells. The exact role of these proteins in mechanoelectrical transduction is unknown. TMC1 and TMC2 are viable candidates for the mechanoelectrical transduction channel of hair cells, whose component molecules have eluded identification for over 30 years. We expect that studies of TMC proteins will yield insights into molecular components and mechanisms of mechanosensation in auditory and vestibular hair cells, as well as in other tissues and organs. Mutations of the transmembrane channel-like 1 ( TMC1 ) gene can cause dominant and recessive forms of deafness in humans and mice. TMC1 is one of eight mammalian TMC genes of unknown function. The multi-pass transmembrane topologic structure of the proteins they encode suggests roles as a receptor, transporter, channel, or pump. Tmc1 and the closely related Tmc2 gene are expressed in neurosensory hair cells of the auditory and vestibular end organs of the mouse inner ear. Recent studies have demonstrated that Tmc1 and Tmc2 are specifically required for mechanoelectrical transduction in hair cells. The exact role of these proteins in mechanoelectrical transduction is unknown. TMC1 and TMC2 are viable candidates for the mechanoelectrical transduction channel of hair cells, whose component molecules have eluded identification for over 30 years. We expect that studies of TMC proteins will yield insights into molecular components and mechanisms of mechanosensation in auditory and vestibular hair cells, as well as in other tissues and organs.
Author	Griffith, Andrew J. Holt, Jeffrey R. Kawashima, Yoshiyuki Pan, Bifeng Kurima, Kiyoto
AuthorAffiliation	3 Department of Otolaryngology, F.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA 2 Molecular Biology and Genetics Section, National Institute on Deafness and Other Communication Disorders (NIDCD), National Institutes of Health, Bethesda, Maryland, 20892, USA 1 Department of Otolaryngology, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, 113-8519, Japan
AuthorAffiliation_xml	– name: 1 Department of Otolaryngology, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, 113-8519, Japan – name: 2 Molecular Biology and Genetics Section, National Institute on Deafness and Other Communication Disorders (NIDCD), National Institutes of Health, Bethesda, Maryland, 20892, USA – name: 3 Department of Otolaryngology, F.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA
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Cites_doi	10.1523/JNEUROSCI.4086-13.2014 10.1016/S0888-7543(03)00154-X 10.1136/bmj.323.7312.536 10.1016/0896-6273(91)90293-9 10.1038/nature11845 10.1111/j.1399-0004.2007.00739.x 10.1523/JNEUROSCI.1163-06.2006 10.1085/jgp.201210913 10.1159/000313282 10.1016/j.neuron.2013.06.019 10.1016/j.ydbio.2005.01.015 10.1056/NEJMra050700 10.1113/jphysiol.2005.095661 10.1038/ng848 10.1097/00129492-200409000-00011 10.1002/ajmg.1320460504 10.1152/jn.00136.2009 10.1534/genetics.106.057372 10.1038/nature06091 10.1038/ng842 10.1038/nn1120 10.1021/bi1004377 10.1038/288159a0 10.1038/nn.2295 10.1371/journal.pone.0097064 10.1016/j.cell.2009.09.010 10.1016/j.neuroscience.2005.01.046 10.1016/j.ajhg.2012.12.015 10.1186/1471-2164-4-24 10.1111/j.1399-0004.2009.01338.x 10.1085/jgp.201411173 10.1172/JCI60405
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Keywords	Mechanosensory TMC1 Deafness Hearing Mechanoelectrical Channel Hair cell Mechanotransduction Transduction TMC2
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Snippet	Mutations of the transmembrane channel-like 1 ( TMC1 ) gene can cause dominant and recessive forms of deafness in humans and mice. TMC1 is one of eight... Mutations of the transmembrane channel-like 1 (TMC1) gene can cause dominant and recessive forms of deafness in humans and mice. TMC1 is one of eight mammalian... Issue Title: Physiological Aspects of Mechanosensing Mutations of the transmembrane channel-like 1 (TMC1) gene can cause dominant and recessive forms of...
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SubjectTerms	Animals Biomedical and Life Sciences Biomedicine Cell Biology Hair Cells, Auditory - physiology Hair Cells, Vestibular - physiology Hearing - physiology Human Physiology Humans Invited Review Ion Channel Gating - physiology Ion Channels - physiology Mechanotransduction, Cellular - physiology Molecular Medicine Neurosciences Postural Balance - physiology Receptors
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Title	Transmembrane channel-like (TMC) genes are required for auditory and vestibular mechanosensation
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