A human brainstem glioma xenograft model enabled for bioluminescence imaging

• Published in: Journal of neuro-oncology Vol. 96; no. 2; pp. 151 - 159
• Main Authors: Hashizume, Rintaro, Ozawa, Tomoko, Dinca, Eduard B., Banerjee, Anuradha, Prados, Michael D., James, Charles D., Gupta, Nalin
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.01.2010; Springer Nature B.V
• Subjects: Animals; Antineoplastic Agents, Alkylating - therapeutic use; Brain Stem Neoplasms - diagnosis; Brain Stem Neoplasms - drug therapy; Cell Line, Tumor; Dacarbazine - analogs & derivatives; Dacarbazine - therapeutic use; Diagnostic Imaging; Disease Models, Animal; Glioma - diagnosis; Glioma - drug therapy; Humans; In Situ Nick-End Labeling - methods; Kaplan-Meier Estimate; Laboratory Investigation - Human/Animal Tissue; Luciferases; Luminescent Agents; Male; Medicine; Medicine & Public Health; Neoplasm Transplantation - methods; Neurology; Oncology; Rats; Rats, Nude; Temozolomide; Time Factors; Xenograft Model Antitumor Assays - methods; Brainstem tumor; Animal model; Bioluminescence; Temozolomide

Despite the use of radiation and chemotherapy, the prognosis for children with diffuse brainstem gliomas is extremely poor. There is a need for relevant brainstem tumor models that can be used to test new therapeutic agents and delivery systems in pre-clinical studies. We report the development of a...