MYB: A Key Transcription Factor in the Hematopoietic System Subject to Many Levels of Control

• Published in: Advances in experimental medicine and biology Vol. 1459; p. 3
• Main Authors: Lemma, Roza Berhanu, Fuglerud, Bettina Maria, Frampton, Jon, Gabrielsen, Odd Stokke
• Format: Journal Article
• Language: English
• Published: United States 2024
• Subjects: Animals; Epigenesis, Genetic; Gene Expression Regulation; Hematopoiesis - genetics; Hematopoietic Stem Cells - metabolism; Humans; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-myb - genetics; Proto-Oncogene Proteins c-myb - metabolism; Target genes; SUMO; Enhancer; c-Myb; MYB; Pioneer factor; Epigenetic regulator; Transcription factor

MYB is a master regulator and pioneer factor highly expressed in hematopoietic progenitor cells (HPCs) where it contributes to the reprogramming processes operating during hematopoietic development. MYB plays a complex role being involved in several lineages of the hematopoietic system. At the molec...