The 5-HT1A receptor and 5-HT transporter in temporal lobe epilepsy

• Published in: Neurology Vol. 80; no. 16; p. 1465
• Main Authors: Martinez, Ashley, Finegersh, Andrey, Cannon, Dara M, Dustin, Irene, Nugent, Alison, Herscovitch, Peter, Theodore, William H
• Format: Journal Article
• Language: English
• Published: United States 16.04.2013
• Subjects: Adult; Age of Onset; Analysis of Variance; Anticonvulsants - therapeutic use; Benzylamines; Cerebral Cortex - diagnostic imaging; Cerebral Cortex - metabolism; Cyclohexanes; Data Interpretation, Statistical; Depression - etiology; Depression - genetics; Depression - psychology; Depressive Disorder, Major - etiology; Depressive Disorder, Major - genetics; Diagnostic and Statistical Manual of Mental Disorders; Epilepsy, Temporal Lobe - diagnostic imaging; Epilepsy, Temporal Lobe - genetics; Epilepsy, Temporal Lobe - psychology; Female; Functional Laterality - physiology; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Piperazines; Positron-Emission Tomography; Psychiatric Status Rating Scales; Radiopharmaceuticals; Receptor, Serotonin, 5-HT1A - genetics; Serotonin Plasma Membrane Transport Proteins - genetics; Sex Characteristics

To study 5-HT transport and 5-HT1A receptors in temporal lobe epilepsy (TLE) and depression. Thirteen patients had PET with [(11)C]DASB for 5-HTT and [(18)F]FCWAY for 5-HT1A receptor binding, MRI, and psychiatric assessment. Sixteen healthy volunteers had [(11)C]DASB, 19 had [(18)F]FCWAY, and 6 had...