CD137 Is Expressed in Follicular Dendritic Cell Tumors and in Classical Hodgkin and T-Cell Lymphomas: Diagnostic and Therapeutic Implications
CD137 (also known as 4-1BB and TNFRSF9) is a member of the tumor necrosis factor receptor superfamily. Originally identified as a costimulatory molecule expressed by activated T cells and NK cells, CD137 is also expressed by follicular dendritic cells, monocytes, mast cells, granulocytes, and endoth...
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Published in | The American journal of pathology Vol. 181; no. 3; pp. 795 - 803 |
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Main Authors | , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Bethesda, MD
American Society for Investigative Pathology
01.09.2012
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Subjects | |
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Abstract | CD137 (also known as 4-1BB and TNFRSF9) is a member of the tumor necrosis factor receptor superfamily. Originally identified as a costimulatory molecule expressed by activated T cells and NK cells, CD137 is also expressed by follicular dendritic cells, monocytes, mast cells, granulocytes, and endothelial cells. Anti-CD137 immunotherapy has recently shown promise as a treatment for solid tumors and lymphoid malignancies in preclinical models. We defined the expression of CD137 protein in both normal and neoplastic hematolymphoid tissue. CD137 protein is expressed by follicular dendritic cells in the germinal center and scattered paracortical T cells, but not by normal germinal-center B cells, bone marrow progenitor cells, or maturing thymocytes. CD137 protein is expressed by a select group of hematolymphoid tumors, including classical Hodgkin lymphoma, T-cell and NK/T-cell lymphomas, and follicular dendritic cells neoplasms. CD137 is a novel diagnostic marker of these tumors and suggests a possible target for tumor-directed antibody therapy. |
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AbstractList | CD137 (also known as 4-1BB and TNFRSF9) is a member of the tumor necrosis factor receptor superfamily. Originally identified as a costimulatory molecule expressed by activated T cells and NK cells, CD137 is also expressed by follicular dendritic cells, monocytes, mast cells, granulocytes, and endothelial cells. Anti-CD137 immunotherapy has recently shown promise as a treatment for solid tumors and lymphoid malignancies in preclinical models. We defined the expression of CD137 protein in both normal and neoplastic hematolymphoid tissue. CD137 protein is expressed by follicular dendritic cells in the germinal center and scattered paracortical T cells, but not by normal germinal-center B cells, bone marrow progenitor cells, or maturing thymocytes. CD137 protein is expressed by a select group of hematolymphoid tumors, including classical Hodgkin lymphoma, T-cell and NK/T-cell lymphomas, and follicular dendritic cells neoplasms. CD137 is a novel diagnostic marker of these tumors and suggests a possible target for tumor-directed antibody therapy. |
Author | FREUD, Aharon G CZERWINSKI, Debra K MORAIS, José Carlos LEVY, Ronald ANDERSON, Matthew W ALIZADEH, Ash A AZAMBUJA, Denize BIASOLI, Irene KOHRT, Holbrook MOLINA-KIRSCH, Hernan F SPECTOR, Nelson HOUOT, Roch WARNKE, Roger A NATKUNAM, Yasodha SHUCHUN ZHAO |
AuthorAffiliation | Department of Pathology, San Juan Hospital, Guatemala City, Guatemala Clinical Hematology Service, CHU Rennes, Rennes, France Federal University of Rio de Janeiro, Rio de Janeiro, Brazil Department of Pathology, Stanford University School of Medicine, Stanford, California INSERM U917, Rennes, France Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, California |
AuthorAffiliation_xml | – name: Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, California – name: Department of Pathology, Stanford University School of Medicine, Stanford, California – name: Department of Pathology, San Juan Hospital, Guatemala City, Guatemala – name: INSERM U917, Rennes, France – name: Federal University of Rio de Janeiro, Rio de Janeiro, Brazil – name: Clinical Hematology Service, CHU Rennes, Rennes, France |
Author_xml | – sequence: 1 givenname: Matthew W surname: ANDERSON fullname: ANDERSON, Matthew W organization: Department of Pathology, Stanford University School of Medicine, Stanford, California, United States – sequence: 2 surname: SHUCHUN ZHAO fullname: SHUCHUN ZHAO organization: Department of Pathology, Stanford University School of Medicine, Stanford, California, United States – sequence: 3 givenname: Nelson surname: SPECTOR fullname: SPECTOR, Nelson organization: Federal University of Rio de Janeiro, Rio de Janeiro, Brazil – sequence: 4 givenname: Hernan F surname: MOLINA-KIRSCH fullname: MOLINA-KIRSCH, Hernan F organization: Department of Pathology, San Juan Hospital, Guatemala City, Guatemala – sequence: 5 givenname: Roger A surname: WARNKE fullname: WARNKE, Roger A organization: Department of Pathology, Stanford University School of Medicine, Stanford, California, United States – sequence: 6 givenname: Ronald surname: LEVY fullname: LEVY, Ronald organization: Division of Oncology, Stanford University School of Medicine, Stanford, California, United States – sequence: 7 givenname: Yasodha surname: NATKUNAM fullname: NATKUNAM, Yasodha organization: Department of Pathology, Stanford University School of Medicine, Stanford, California, United States – sequence: 8 givenname: Aharon G surname: FREUD fullname: FREUD, Aharon G organization: Department of Pathology, Stanford University School of Medicine, Stanford, California, United States – sequence: 9 givenname: Debra K surname: CZERWINSKI fullname: CZERWINSKI, Debra K organization: Division of Oncology, Stanford University School of Medicine, Stanford, California, United States – sequence: 10 givenname: Holbrook surname: KOHRT fullname: KOHRT, Holbrook organization: Division of Oncology, Stanford University School of Medicine, Stanford, California, United States – sequence: 11 givenname: Ash A surname: ALIZADEH fullname: ALIZADEH, Ash A organization: Division of Oncology, Stanford University School of Medicine, Stanford, California, United States – sequence: 12 givenname: Roch surname: HOUOT fullname: HOUOT, Roch organization: Department of Medicine, Stanford University School of Medicine, Stanford, California, United States – sequence: 13 givenname: Denize surname: AZAMBUJA fullname: AZAMBUJA, Denize organization: Federal University of Rio de Janeiro, Rio de Janeiro, Brazil – sequence: 14 givenname: Irene surname: BIASOLI fullname: BIASOLI, Irene organization: Federal University of Rio de Janeiro, Rio de Janeiro, Brazil – sequence: 15 givenname: José Carlos surname: MORAIS fullname: MORAIS, José Carlos organization: Federal University of Rio de Janeiro, Rio de Janeiro, Brazil |
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Keywords | Dendritic cell T lymphoma Follicular cell Hodgkin disease Malignant hemopathy Costimulatory molecule Anatomic pathology Treatment Antigen presenting cell Lymphoproliferative syndrome Costimulatory receptor 4-1BB Tumor Diagnosis Cancer |
Language | English |
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SubjectTerms | Biological and medical sciences Biomarkers, Tumor - metabolism Dendritic Cells, Follicular - metabolism Dendritic Cells, Follicular - pathology Flow Cytometry Hematologic and hematopoietic diseases Histiocytic Disorders, Malignant - diagnosis Histiocytic Disorders, Malignant - metabolism Histiocytic Disorders, Malignant - pathology Histiocytic Disorders, Malignant - therapy Hodgkin Disease - diagnosis Hodgkin Disease - metabolism Hodgkin Disease - pathology Hodgkin Disease - therapy Humans Immunohistochemistry Investigative techniques, diagnostic techniques (general aspects) Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphocyte Subsets - metabolism Lymphoid Tissue - metabolism Lymphoid Tissue - pathology Lymphoma, B-Cell - metabolism Lymphoma, B-Cell - pathology Lymphoma, T-Cell - diagnosis Lymphoma, T-Cell - metabolism Lymphoma, T-Cell - pathology Lymphoma, T-Cell - therapy Medical sciences Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Regular Tumor Necrosis Factor Receptor Superfamily, Member 9 - metabolism |
Title | CD137 Is Expressed in Follicular Dendritic Cell Tumors and in Classical Hodgkin and T-Cell Lymphomas: Diagnostic and Therapeutic Implications |
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