Discoidin Domain Receptor 1: Isoform Expression and Potential Functions in Cirrhotic Human Liver

• Published in: The American journal of pathology Vol. 178; no. 3; pp. 1134 - 1144
• Main Authors: SUNMI SONG, SHACKEL, Nicholas A, WANG, Xin M, AJAMI, Katerina, MCCAUGHAN, Geoffrey W, GORRELL, Mark D
• Format: Journal Article
• Language: English
• Published: Bethesda, MD American Society for Investigative Pathology 01.03.2011
• Subjects: Adolescent; Adult; Biological and medical sciences; Cell Adhesion; Cell Line; Cell Movement; Discoidin Domain Receptor 1; Female; Gastroenterology. Liver. Pancreas. Abdomen; Gene Expression Regulation; Green Fluorescent Proteins - metabolism; Humans; Immunohistochemistry; Investigative techniques, diagnostic techniques (general aspects); Liver - enzymology; Liver - pathology; Liver Cirrhosis - enzymology; Liver Cirrhosis - pathology; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Male; Matrix Metalloproteinases - metabolism; Medical sciences; Middle Aged; Other diseases. Semiology; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; Protein Isoforms - chemistry; Protein Isoforms - genetics; Protein Isoforms - metabolism; Receptor Protein-Tyrosine Kinases - chemistry; Receptor Protein-Tyrosine Kinases - genetics; Receptor Protein-Tyrosine Kinases - metabolism; Recombinant Fusion Proteins - metabolism; Regular; RNA, Messenger - genetics; RNA, Messenger - metabolism; Transfection; Young Adult; Human; Cirrhosis; Discoidin domain receptor 1; Anatomic pathology; Molecular form; Digestive system; Liver; Digestive diseases; Hepatic disease; trk receptor

Discoidin domain receptor 1 (DDR1) is a receptor tyrosine kinase that binds and is activated by collagens. Transcriptional profiling of cirrhosis in human liver using a DNA array and quantitative PCR detected elevated mRNA expression of DDR1 compared with that in nondiseased liver. The present study...