Oxygen therapy for patients with COPD: current evidence and the long-term oxygen treatment trial

Long-term use of supplemental oxygen improves survival in patients with COPD and severe resting hypoxemia. However, the role of oxygen in symptomatic patients with COPD and more moderate hypoxemia at rest and desaturation with activity is unclear. The few long-term reports of supplemental oxygen in...

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Published inChest Vol. 138; no. 1; p. 179
Main Authors Stoller, James K, Panos, Ralph J, Krachman, Samuel, Doherty, Dennis E, Make, Barry
Format Journal Article
LanguageEnglish
Published United States 01.07.2010
Subjects
Follow-Up Studies
Humans
Oxygen Inhalation Therapy - methods
Pulmonary Disease, Chronic Obstructive - therapy
Randomized Controlled Trials as Topic
Time Factors
Treatment Outcome
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Abstract Long-term use of supplemental oxygen improves survival in patients with COPD and severe resting hypoxemia. However, the role of oxygen in symptomatic patients with COPD and more moderate hypoxemia at rest and desaturation with activity is unclear. The few long-term reports of supplemental oxygen in this group have been of small size and insufficient to demonstrate a survival benefit. Short-term trials have suggested beneficial effects other than survival in patients with COPD and moderate hypoxemia at rest. In addition, supplemental oxygen appeared to improve exercise performance in small short-term investigations of patients with COPD and moderate hypoxemia at rest and desaturation with exercise, but long-term trials evaluating patient-reported outcomes are lacking. This article reviews the evidence for long-term use of supplemental oxygen therapy and provides a rationale for the National Heart, Lung, and Blood Institute Long-term Oxygen Treatment Trial. The trial plans to enroll subjects with COPD with moderate hypoxemia at rest or desaturation with exercise and compare tailored oxygen therapy to no oxygen therapy.
AbstractList Long-term use of supplemental oxygen improves survival in patients with COPD and severe resting hypoxemia. However, the role of oxygen in symptomatic patients with COPD and more moderate hypoxemia at rest and desaturation with activity is unclear. The few long-term reports of supplemental oxygen in this group have been of small size and insufficient to demonstrate a survival benefit. Short-term trials have suggested beneficial effects other than survival in patients with COPD and moderate hypoxemia at rest. In addition, supplemental oxygen appeared to improve exercise performance in small short-term investigations of patients with COPD and moderate hypoxemia at rest and desaturation with exercise, but long-term trials evaluating patient-reported outcomes are lacking. This article reviews the evidence for long-term use of supplemental oxygen therapy and provides a rationale for the National Heart, Lung, and Blood Institute Long-term Oxygen Treatment Trial. The trial plans to enroll subjects with COPD with moderate hypoxemia at rest or desaturation with exercise and compare tailored oxygen therapy to no oxygen therapy.
Author Krachman, Samuel
Doherty, Dennis E
Make, Barry
Stoller, James K
Panos, Ralph J
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References 1586049 - Am Rev Respir Dis. 1992 May;145(5):1070-6
2578248 - Am J Med. 1985 Jan;78(1):28-34
1541127 - Chest. 1992 Mar;101(3):649-55
7582304 - Am J Respir Crit Care Med. 1995 Nov;152(5 Pt 1):1616-9
16899358 - Respir Med. 2007 Mar;101(3):561-7
9272911 - Eur Respir J. 1997 Aug;10(8):1730-5
12869359 - Am J Respir Crit Care Med. 2003 Nov 1;168(9):1034-42
16304265 - Chest. 2005 Nov;128(5):3221-8
2298055 - Chest. 1990 Feb;97(2):308-12
433964 - Am J Med. 1979 Apr;66(4):573-9
6110912 - Lancet. 1981 Mar 28;1(8222):681-6
4753639 - Am J Med. 1973 Dec;55(6):736-46
17443585 - Cochrane Database Syst Rev. 2007;(2):CD005372
6776858 - Ann Intern Med. 1980 Sep;93(3):391-8
15963198 - Int J Clin Pract. 2005 Jul;59(7):751-3
16235285 - Cochrane Database Syst Rev. 2005;(4):CD001744
9192929 - Eur Respir J. 1997 Jun;10(6):1278-84
18625667 - Chest. 2008 Oct;134(4):746-52
15316206 - Respiration. 2004 Jul-Aug;71(4):342-7
421531 - Chest. 1979 Jan;75(1):8-11
6112324 - Lancet. 1981 Apr 25;1(8226):907-9
3538488 - Thorax. 1986 Aug;41(8):611-5
15282379 - Thorax. 2004 Aug;59(8):638-40
17494825 - Chest. 2007 May;131(5 Suppl):4S-42S
12212960 - Eur Respir J. 2002 Aug;20(2):306-12
11510809 - Eur Respir J. 2001 Jul;18(1):77-84
16614349 - Am J Respir Crit Care Med. 2006 Aug 15;174(4):373-8
3353874 - Thorax. 1988 Jan;43(1):53-6
3824271 - Thorax. 1986 Nov;41(11):846-54
3652746 - Chest. 1987 Oct;92(4):604-8
7103244 - Am Rev Respir Dis. 1982 Aug;126(2):206-10
11029341 - Am J Respir Crit Care Med. 2000 Oct;162(4 Pt 1):1335-41
12749552 - Sleep. 2003 May 1;26(3):318-23
236652 - Am J Med. 1975 May;58(5):663-70
6799253 - Chest. 1982 Feb;81(2):182-8
18641094 - Chest. 2008 Sep;134(3):497-506
12885981 - Thorax. 2003 Aug;58(8):670-3
7654114 - Arch Intern Med. 1995 Sep 11;155(16):1797-800
2924605 - Chest. 1989 Apr;95(4):757-64
16737805 - Respir Med. 2006 Jul;100(7):1129-38
12171815 - Chest. 2002 Aug;122(2):445-50
10856311 - Thorax. 2000 Jul;55(7):544-6
8275723 - Chest. 1994 Jan;105(1):151-4
9337824 - Thorax. 1997 Aug;52(8):674-9
16710952 - Respir Care. 2006 May;51(5):519-25
6797795 - Chest. 1982 Jan;81(1):6-10
14617262 - Clin Physiol Funct Imaging. 2003 Nov;23(6):324-31
3922267 - Am Rev Respir Dis. 1985 Apr;131(4):493-8
15282386 - Thorax. 2004 Aug;59(8):668-72
14582907 - Eur Respir J. 2003 Oct;22(4):584-8
9440570 - Chest. 1998 Jan;113(1):65-70
11585150 - J Rehabil Med. 2001 Sep;33(5):200-5
7125332 - Am Rev Respir Dis. 1982 Sep;126(3):429-33
7846340 - Respir Med. 1994 Nov;88(10):777-85
10596681 - Eur Respir J. 1999 Nov;14(5):1002-8
11502641 - Chest. 2001 Aug;120(2):437-43
References_xml – reference: 8275723 - Chest. 1994 Jan;105(1):151-4
– reference: 7125332 - Am Rev Respir Dis. 1982 Sep;126(3):429-33
– reference: 7846340 - Respir Med. 1994 Nov;88(10):777-85
– reference: 16614349 - Am J Respir Crit Care Med. 2006 Aug 15;174(4):373-8
– reference: 2924605 - Chest. 1989 Apr;95(4):757-64
– reference: 3652746 - Chest. 1987 Oct;92(4):604-8
– reference: 11585150 - J Rehabil Med. 2001 Sep;33(5):200-5
– reference: 17494825 - Chest. 2007 May;131(5 Suppl):4S-42S
– reference: 3353874 - Thorax. 1988 Jan;43(1):53-6
– reference: 16899358 - Respir Med. 2007 Mar;101(3):561-7
– reference: 18641094 - Chest. 2008 Sep;134(3):497-506
– reference: 433964 - Am J Med. 1979 Apr;66(4):573-9
– reference: 16304265 - Chest. 2005 Nov;128(5):3221-8
– reference: 7582304 - Am J Respir Crit Care Med. 1995 Nov;152(5 Pt 1):1616-9
– reference: 7103244 - Am Rev Respir Dis. 1982 Aug;126(2):206-10
– reference: 15316206 - Respiration. 2004 Jul-Aug;71(4):342-7
– reference: 3824271 - Thorax. 1986 Nov;41(11):846-54
– reference: 6112324 - Lancet. 1981 Apr 25;1(8226):907-9
– reference: 11510809 - Eur Respir J. 2001 Jul;18(1):77-84
– reference: 14582907 - Eur Respir J. 2003 Oct;22(4):584-8
– reference: 1586049 - Am Rev Respir Dis. 1992 May;145(5):1070-6
– reference: 12749552 - Sleep. 2003 May 1;26(3):318-23
– reference: 9192929 - Eur Respir J. 1997 Jun;10(6):1278-84
– reference: 15963198 - Int J Clin Pract. 2005 Jul;59(7):751-3
– reference: 3538488 - Thorax. 1986 Aug;41(8):611-5
– reference: 17443585 - Cochrane Database Syst Rev. 2007;(2):CD005372
– reference: 12171815 - Chest. 2002 Aug;122(2):445-50
– reference: 12212960 - Eur Respir J. 2002 Aug;20(2):306-12
– reference: 10856311 - Thorax. 2000 Jul;55(7):544-6
– reference: 9440570 - Chest. 1998 Jan;113(1):65-70
– reference: 1541127 - Chest. 1992 Mar;101(3):649-55
– reference: 9337824 - Thorax. 1997 Aug;52(8):674-9
– reference: 11502641 - Chest. 2001 Aug;120(2):437-43
– reference: 2298055 - Chest. 1990 Feb;97(2):308-12
– reference: 15282386 - Thorax. 2004 Aug;59(8):668-72
– reference: 6799253 - Chest. 1982 Feb;81(2):182-8
– reference: 15282379 - Thorax. 2004 Aug;59(8):638-40
– reference: 6110912 - Lancet. 1981 Mar 28;1(8222):681-6
– reference: 9272911 - Eur Respir J. 1997 Aug;10(8):1730-5
– reference: 6776858 - Ann Intern Med. 1980 Sep;93(3):391-8
– reference: 7654114 - Arch Intern Med. 1995 Sep 11;155(16):1797-800
– reference: 12869359 - Am J Respir Crit Care Med. 2003 Nov 1;168(9):1034-42
– reference: 11029341 - Am J Respir Crit Care Med. 2000 Oct;162(4 Pt 1):1335-41
– reference: 2578248 - Am J Med. 1985 Jan;78(1):28-34
– reference: 16710952 - Respir Care. 2006 May;51(5):519-25
– reference: 16737805 - Respir Med. 2006 Jul;100(7):1129-38
– reference: 18625667 - Chest. 2008 Oct;134(4):746-52
– reference: 6797795 - Chest. 1982 Jan;81(1):6-10
– reference: 421531 - Chest. 1979 Jan;75(1):8-11
– reference: 4753639 - Am J Med. 1973 Dec;55(6):736-46
– reference: 10596681 - Eur Respir J. 1999 Nov;14(5):1002-8
– reference: 16235285 - Cochrane Database Syst Rev. 2005;(4):CD001744
– reference: 14617262 - Clin Physiol Funct Imaging. 2003 Nov;23(6):324-31
– reference: 236652 - Am J Med. 1975 May;58(5):663-70
– reference: 3922267 - Am Rev Respir Dis. 1985 Apr;131(4):493-8
– reference: 12885981 - Thorax. 2003 Aug;58(8):670-3
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Snippet Long-term use of supplemental oxygen improves survival in patients with COPD and severe resting hypoxemia. However, the role of oxygen in symptomatic patients...
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SubjectTerms Follow-Up Studies
Humans
Oxygen Inhalation Therapy - methods
Pulmonary Disease, Chronic Obstructive - therapy
Randomized Controlled Trials as Topic
Time Factors
Treatment Outcome
Title Oxygen therapy for patients with COPD: current evidence and the long-term oxygen treatment trial
URI https://www.ncbi.nlm.nih.gov/pubmed/20605816
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