Sulforaphane induces S-phase arrest and apoptosis via p53-dependent manner in gastric cancer cells

• Published in: Scientific reports Vol. 11; no. 1; p. 2504
• Main Authors: Wang, Yuan, Wu, Huazhang, Dong, Nannan, Su, Xu, Duan, Mingxiu, Wei, Yaqin, Wei, Jun, Liu, Gaofeng, Peng, Qingjie, Zhao, Yunli
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 28.01.2021; Nature Publishing Group UK
• Subjects: Anticarcinogenic Agents - pharmacology; Antitumor activity; Apoptosis; Apoptosis - drug effects; Apoptosis - genetics; Autophagy-Related Protein 5 - genetics; Autophagy-Related Protein 5 - metabolism; Caspase-3; Cell cycle; Cell growth; Cell Line, Tumor; Cell proliferation; Cell Proliferation - drug effects; Cell Survival - drug effects; Cyclin-dependent kinase 2; Dose-Response Relationship, Drug; Flow cytometry; Gastric cancer; Humans; Isothiocyanates - pharmacology; p53 Protein; Phase transitions; S phase; S Phase Cell Cycle Checkpoints - drug effects; S Phase Cell Cycle Checkpoints - genetics; Stomach Neoplasms; Sulforaphane; Sulfoxides - pharmacology; Tumor Suppressor Protein p53 - genetics; Tumor Suppressor Protein p53 - metabolism

Sulforaphane (SFN) extracted from broccoli sprout has previously been investigated for its potential properties in cancers, however, the underlying mechanisms of the anticancer activity of SFN remain not fully understood. In the present study, we investigate the effects of SFN on cell proliferation,...