Drug Concentration Asymmetry in Tissues and Plasma for Small Molecule-Related Therapeutic Modalities - Zhang, Donglu; Hop, Cornelis E C A; Patilea-Vrana, Gabriela; Gampa, Gautham; Seneviratne, Herana Kamal; Unadkat, Jashvant D; Kenny, Jane R; Nagapudi, Karthik; Di, Li; Zhou, Lian; Zak, Mark; Wright, Matthew R; et al. (Drug metabolism and disposition, 2019)
Keywords: Animals; Antibodies; Asymmetry; Binders; Biotransformation; Cell Membrane - metabolism; Chemical compounds; Drug delivery; Drug delivery systems; Drug development; Drug Discovery - methods; Drugs; Efflux; Extrusion; Forecasting; Humans; Immunoconjugates - pharmacokinetics; Inhalation; Membrane Transport Proteins - metabolism; Minireview; Nanoparticles; Optimization; Pharmacodynamics; Pharmacokinetics; Pharmacology; Plasma; Plasma - metabolism; Prodrugs; Prodrugs - pharmacokinetics; Respiration; Steady state; Therapeutic applications; Tissue Distribution; Tissues