Genotype, allele and haplotype frequencies of four TCL1A gene polymorphisms associated with musculoskeletal toxicity in the South Indian descent

• Published in: BioImpacts : BI Vol. 4; no. 2; pp. 95 - 100
• Main Authors: Umamaheswaran, Gurusamy, Dkhar, Steven Aibor, Kumar, Annan Sudarsan Arun, Srinivasa, Rao Katiboina, Kadambari, Dharanipragada, Adithan, Chandrasekaran
• Format: Journal Article
• Language: English
• Published: Iran Tabriz University of Medical Sciences 01.01.2014
• Subjects: Biomarkers; Breast cancer; Cancer therapies; Confidence intervals; Deoxyribonucleic acid; DNA; Genealogy; Genes; Genomes; Haplotypes; Pain; Population; Proteins; Software; Studies; Toxicity; Womens health; Linkage disequilibrium South Indians; TCL1A; Breast cancer; SNP; Aromatase

Decline in circulating estrogen levels causes lessening of bone mass accompanied with musculoskeletal pain, which is the primary cause of treatment discontinuation in patients taking aromatase inhibitors. Evidence from recent genome-wide association studies (GWAS) suggests that the genetic variabili...