A new synthetic derivative of cryptotanshinone KYZ3 as STAT3 inhibitor for triple-negative breast cancer therapy - Zhang, Wenda; Yu, Wenying; Cai, Guiping; Zhu, Jiawen; Zhang, Chao; Li, Shanshan; Guo, Jianpeng; Yin, Guoping; Chen, Chen; Kong, Lingyi (Cell death & disease, 2018)
Keywords: Active Transport, Cell Nucleus - drug effects; Animals; Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - pharmacology; Antitumor activity; Apoptosis; Apoptosis - drug effects; Apoptosis - genetics; Bax protein; Bcl-2 protein; bcl-2-Associated X Protein - genetics; bcl-2-Associated X Protein - metabolism; Breast cancer; Cancer therapies; Cell Movement - drug effects; Cell Proliferation - drug effects; Cryptotanshinone; Female; Gelatinase B; Gene Expression Regulation, Neoplastic; Humans; MCF-7 Cells; Metastases; Mice; Mice, Inbred BALB C; Mice, Nude; Natural products; Neoplasm Invasiveness; Nuclear transport; Phenanthrenes - chemical synthesis; Phenanthrenes - pharmacology; Phosphorylation; Phosphorylation - drug effects; Protein transport; Proto-Oncogene Proteins c-bcl-2 - genetics; Proto-Oncogene Proteins c-bcl-2 - metabolism; Signal Transduction; Stat3 protein; STAT3 Transcription Factor - antagonists & inhibitors; STAT3 Transcription Factor - genetics; STAT3 Transcription Factor - metabolism; Triple Negative Breast Neoplasms - drug therapy; Triple Negative Breast Neoplasms - genetics; Triple Negative Breast Neoplasms - metabolism; Triple Negative Breast Neoplasms - pathology; Tumors; Xenograft Model Antitumor Assays