Quantitative evaluation of drug or device effects on ventricular remodeling as predictors of therapeutic effects on mortality in patients with heart failure and reduced ejection fraction: a meta-analytic approach

• Published in: Journal of the American College of Cardiology Vol. 56; no. 5; pp. 392 - 406
• Main Authors: Kramer, Daniel G, Trikalinos, Thomas A, Kent, David M, Antonopoulos, George V, Konstam, Marvin A, Udelson, James E
• Format: Journal Article
• Language: English
• Published: United States Elsevier Limited 27.07.2010
• Subjects: Algorithms; Cardiology; Confidence intervals; Drug therapy; Fractions; Heart attacks; Heart failure; Heart Failure - mortality; Heart Failure - physiopathology; Heart Failure - therapy; Heart Ventricles - pathology; Heart-Assist Devices; Human subjects; Humans; Intervention; ISDN; Mortality; Odds Ratio; Placebos; Randomized Controlled Trials as Topic; Regression Analysis; Stroke Volume - drug effects; Studies; Treatment Outcome; Ventricular Dysfunction, Left - mortality; Ventricular Dysfunction, Left - physiopathology; Ventricular Dysfunction, Left - therapy; Ventricular Remodeling

The purpose of this study was to quantitatively assess the relationship between therapy-induced changes in left ventricular (LV) remodeling and longer-term outcomes in patients with left ventricular dysfunction (LVD). Whether therapy-induced changes in left ventricular ejection fraction (LVEF), end-...