Molecular basis of vitamin E action: tocotrienol modulates 12-lipoxygenase, a key mediator of glutamate-induced neurodegeneration

• Published in: The Journal of biological chemistry Vol. 278; no. 44; pp. 43508 - 43515
• Main Authors: Khanna, Savita, Roy, Sashwati, Ryu, Hoon, Bahadduri, Praveen, Swaan, Peter W, Ratan, Rajiv R, Sen, Chandan K
• Format: Journal Article
• Language: English
• Published: United States 31.10.2003
• Subjects: Animals; Arachidonate 12-Lipoxygenase - metabolism; Binding Sites; Cell Death; Cell Survival; Cells, Cultured; Cytosol - metabolism; Glutamic Acid - metabolism; Glutathione - metabolism; Hippocampus - metabolism; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence; Models, Molecular; Neurodegenerative Diseases - metabolism; Neurons - metabolism; Neurotoxins - pharmacology; Protein Structure, Secondary; Protein Structure, Tertiary; Rats; Rats, Sprague-Dawley; Time Factors; Tocotrienols; Vitamin E - analogs & derivatives; Vitamin E - metabolism; Vitamin E - pharmacology; Vitamin E - physiology

Vitamin E is a generic term for tocopherols and tocotrienols. This work is based on our striking evidence that, in neuronal cells, nanomolar concentrations of alpha-tocotrienol, but not alpha-tocopherol, block glutamate-induced death by suppressing early activation of c-Src kinase (Sen, C. K., Khann...