Molecular basis of vitamin E action: tocotrienol modulates 12-lipoxygenase, a key mediator of glutamate-induced neurodegeneration - Khanna, Savita; Roy, Sashwati; Ryu, Hoon; Bahadduri, Praveen; Swaan, Peter W; Ratan, Rajiv R; Sen, Chandan K (The Journal of biological chemistry, 2003)
Keywords: Animals; Arachidonate 12-Lipoxygenase - metabolism; Binding Sites; Cell Death; Cell Survival; Cells, Cultured; Cytosol - metabolism; Glutamic Acid - metabolism; Glutathione - metabolism; Hippocampus - metabolism; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence; Models, Molecular; Neurodegenerative Diseases - metabolism; Neurons - metabolism; Neurotoxins - pharmacology; Protein Structure, Secondary; Protein Structure, Tertiary; Rats; Rats, Sprague-Dawley; Time Factors; Tocotrienols; Vitamin E - analogs & derivatives; Vitamin E - metabolism; Vitamin E - pharmacology; Vitamin E - physiology