The molecular mechanism of dopamine-induced apoptosis: identification and characterization of genes that mediate dopamine toxicity

• Published in: Journal of neural transmission. Supplementum no. 60; p. 59
• Main Authors: Barzilai, A, Zilkha-Falb, R, Daily, D, Stern, N, Offen, D, Ziv, I, Melamed, E, Shirvan, A
• Format: Journal Article
• Language: English
• Published: Austria 2000
• Subjects: Animals; Apoptosis - genetics; Cells, Cultured - drug effects; Cells, Cultured - metabolism; Chaperonin 60 - genetics; Chaperonin 60 - metabolism; Chaperonin Containing TCP-1; Chaperonins - genetics; Chick Embryo; Dopamine - genetics; Dopamine - metabolism; Gene Expression Regulation - genetics; Glutaredoxins; Glycoproteins - genetics; Glycoproteins - metabolism; Intercellular Signaling Peptides and Proteins; Mice; Nerve Tissue Proteins - genetics; Nerve Tissue Proteins - metabolism; Neurons - drug effects; Neurons - metabolism; Oxidative Stress - genetics; Oxidoreductases; Parkinson Disease - genetics; Parkinson Disease - metabolism; Proteins - drug effects; Proteins - metabolism; Rats; RNA, Messenger - metabolism; Semaphorin-3A; Up-Regulation - genetics

Parkinson's disease (PD) is a progressive neurological disorder caused by rather selective degeneration of the dopaminergic (DA) neurons in the substantia nigra. Though subject to intensive research, the etiology of this nigral neuronal loss is still enigmatic and treatment is basically symptom...