Ghrelin and Motilin Control Systems in GI Physiology and Therapeutics

• Published in: Gastrointestinal Pharmacology Vol. 239; pp. 379 - 416
• Main Authors: Sanger, Gareth J., Broad, John, Callaghan, Brid, Furness, John B.
• Format: Book Chapter Journal Article
• Language: English
• Published: Switzerland Springer International Publishing AG 01.01.2017; Springer International Publishing
• Series: Handbook of Experimental Pharmacology
• Subjects: Animals; Appetite; Appetite Regulation; Colon; Constipation; Des-acyl ghrelin; Enteric Nervous System - metabolism; Enteric Nervous System - physiopathology; Gastroenterology; Gastrointestinal Agents - therapeutic use; Gastrointestinal Diseases - drug therapy; Gastrointestinal Diseases - metabolism; Gastrointestinal Diseases - physiopathology; Gastrointestinal Motility - drug effects; Gastrointestinal tract; Gastrointestinal Tract - drug effects; Gastrointestinal Tract - innervation; Gastrointestinal Tract - metabolism; Gastrointestinal Tract - physiopathology; Gastroparesis; Ghrelin; Ghrelin - metabolism; Human; Humans; Motilin; Motilin - metabolism; Nausea; Neural Pathways - metabolism; Obestatin; Pharmacology; Physiology; Prader-Willi syndrome; Receptor; Receptors, Gastrointestinal Hormone - agonists; Receptors, Gastrointestinal Hormone - metabolism; Receptors, Ghrelin - agonists; Receptors, Ghrelin - metabolism; Receptors, Neuropeptide - agonists; Receptors, Neuropeptide - metabolism; Signal Transduction - drug effects; Stomach; Appetite; Human; Stomach; Prader-Willi syndrome; Motilin; Des-acyl ghrelin; Gastrointestinal tract; Nausea; Ghrelin; Receptor; Colon; Constipation; Gastroparesis; Obestatin

Ghrelin and motilin are released from gastrointestinal endocrine cells during hunger, to act through G protein-coupled receptors that have closely related amino acid sequences. The actions of ghrelin are more complex than motilin because ghrelin also exists outside the GI tract, it is processed to d...