The effect of GR122311X, a bismuth compound with H2‐antagonist activity, on 24‐hour intragastric acidity

• Published in: Alimentary pharmacology & therapeutics Vol. 5; no. 5; pp. 481 - 490
• Main Authors: PREWETT, E. J., NWOKOLO, C. U., HUDSON, M., SAWYERR, A. M., FRASER, A., POUNDER, R. E.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.10.1991; Blackwell
• Subjects: Adolescent; Adult; Biological and medical sciences; Bismuth - pharmacology; Bismuth - urine; Circadian Rhythm - drug effects; Citrates - pharmacology; Digestive system; Double-Blind Method; Gastric Acid - metabolism; Histamine H2 Antagonists - pharmacology; Humans; Male; Medical sciences; Pharmacology. Drug treatments; Ranitidine - analogs & derivatives; Ranitidine - pharmacology; Human; Stomach; Acids; Digestive system; H2 receptor; Oral administration; Antiulcer agent; Exocrine secretion; Normal; Antihistaminic

SUMMARY GR122311X (ranitidine bismuth citrate Glaxo Group Research Ltd) is a bismuth compound with histamine H2‐receptor antagonist activity. The gastric acid antisecretory activity of three oral dosage regimens of GR122311X was compared with placebo and 150 mg ranitidine b.d. The median 24‐h integr...