UV-induced DNA damage and melanin content in human skin differing in racial/ethnic origin

• Published in: The FASEB journal Vol. 17; no. 9; p. 1177
• Main Authors: Tadokoro, Taketsugu, Kobayashi, Nobuhiko, Zmudzka, Barbara Z, Ito, Shosuke, Wakamatsu, Kazumasa, Yamaguchi, Yuji, Korossy, Katalin S, Miller, Sharon A, Beer, Janusz Z, Hearing, Vincent J
• Format: Journal Article
• Language: English
• Published: United States 01.06.2003
• Subjects: Continental Population Groups; DNA - analysis; DNA - immunology; DNA - radiation effects; DNA Damage; Humans; Immunohistochemistry; Kinetics; Melanins - analysis; Skin - chemistry; Skin - radiation effects; Ultraviolet Rays - adverse effects

DNA damage induced by UV radiation is a critical event in skin photocarcinogenesis. However, the role of racial/ethnic origin in determining individual UV sensitivity remains unclear. In this study, we examined the relationships between melanin content and DNA damage induced by UV exposure in situ i...