Immunohistochemical expression of heparanases 1 and 2 in benign tissue and in invasive neoplasia of the endometrium: a case-control study

• Published in: International journal of gynecological cancer Vol. 25; no. 2; pp. 269 - 278
• Main Authors: Signorini Filho, Roney Cesar, de Azevedo Focchi, Gustavo Rubino, Theodoro, Thérèse Rachell, Pinhal, Maria Aparecida Silva, Nicolau, Sergio Mancini
• Format: Journal Article
• Language: English
• Published: United States Elsevier Limited 01.02.2015
• Subjects: Adult; Aged; Cancer; Case-Control Studies; Endometrial cancer; Endometrial Neoplasms - metabolism; Endometrial Neoplasms - pathology; Endometrium; Endometrium - metabolism; Endometrium - pathology; Female; Glucuronidase - metabolism; Humans; Immunohistochemistry; Middle Aged; Tissue Array Analysis

Our purpose was to compare the expression of heparanase isoforms, in normal and in neoplastic endometrium. In a pioneering way, we sought to evaluate the expression of heparanase 1 (HPSE1) and heparanase 2 (HPSE2) in glandular and in stromal tissues. This is a case-control study, conducted retrospec...