BMP4 enhances anoikis resistance and chemoresistance of breast cancer cells through canonical BMP signaling

• Published in: Journal of cell communication and signaling Vol. 16; no. 2; pp. 191 - 205
• Main Authors: Sharma, Renu, Gogoi, Gayatri, Saikia, Snigdha, Sharma, Amit, Kalita, Deep Jyoti, Sarma, Anupam, Limaye, Anil Mukund, Gaur, Manish Kumar, Bhattacharyya, Jina, Jaganathan, Bithiah Grace
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.06.2022; John Wiley & Sons, Inc
• Subjects: Anoikis; anoikis resistance; Apoptosis; Biomedical and Life Sciences; Biomedicine; Bone morphogenetic protein 4; Bone morphogenetic proteins; Breast cancer; cancer stem cells; CD44 antigen; Cell Biology; Cell fate; Cell proliferation; Cell self-renewal; Chemoresistance; Drug resistance; Life Sciences; Metastases; Metastasis; Metastatic migration; Microenvironments; Research Article; Stem cells; TNBC; Tumor cell lines; Tumors; chemoresistance; Metastatic migration; cancer stem cells; TNBC; anoikis resistance

Bone morphogenetic proteins (BMPs) regulate cell fate during development and mediate cancer progression. In this study, we investigated the role of BMP4 in proliferation, anoikis resistance, metastatic migration, and drug resistance of breast cancer cells. We utilized breast cancer cell lines and cl...