Human herpesvirus 8 infection DNA positivity is associated with low insulin secretion: A case‐control study in a sub‐Saharan African population with diabetes

• Published in: Journal of diabetes Vol. 10; no. 11; pp. 866 - 873
• Main Authors: Lontchi‐Yimagou, Eric, Legoff, Jérôme, Nguewa, Jean‐Louis, Boudou, Philippe, Balti, Eric V., Noubiap, Jean J., Kamwa, Vicky, Atogho‐Tiedeu, Barbara, Azabji‐Kenfack, Marcel, Djahmeni, Eric N., Etoa, Martine, Lemdjo, Gaelle, Balla, Vanessa, Dehayem, Mesmin Y., Foufelle, Fabienne, Mbanya, Jean‐Claude, Gautier, Jean‐Francois, Sobngwi, Eugene
• Format: Journal Article
• Language: English
• Published: Melbourne Wiley Publishing Asia Pty Ltd 01.11.2018; John Wiley & Sons, Inc
• Subjects: 2型糖尿病; 8型人类疱疹病毒; Adult; Biomarkers - blood; Cameroon - epidemiology; Case-Control Studies; Deoxyribonucleic acid; Diabetes; Diabetes Mellitus - blood; Diabetes Mellitus - diagnosis; Diabetes Mellitus - epidemiology; Diabetes Mellitus - virology; DNA; DNA, Viral - genetics; Female; Glucose; Health risk assessment; Herpesviridae Infections - blood; Herpesviridae Infections - diagnosis; Herpesviridae Infections - epidemiology; Herpesviridae Infections - virology; Herpesvirus 8, Human - genetics; Herpesvirus 8, Human - pathogenicity; Host-Pathogen Interactions; human herpesvirus type 8; Humans; Insulin - blood; Insulin resistance; insulin secretion; ketosis‐pronediabetes; Male; Middle Aged; Risk Factors; Secretory Pathway; type 2 diabetes; Viral Load; 胰岛素分泌; 胰岛素抵抗; 酮症倾向性糖尿病; Cameroon; ketosis-pronediabetes; type 2 diabetes; 酮症倾向性糖尿病; 8型人类疱疹病毒; 胰岛素分泌; 胰岛素抵抗; human herpesvirus type 8; insulin secretion; insulin resistance; 2型糖尿病

Background Viruses have been considered potential triggers for the development of diabetes. This study assessed insulin secretion and insulin sensitivity in human herpesvirus 8 (HHV8)‐infected and uninfected sub‐Saharan African people with diabetes. Methods In all, 173 people with non‐autoimmune dia...