Meta‐analysis of associations between XRCC1 gene polymorphisms and susceptibility to systemic lupus erythematosus and rheumatoid arthritis

• Published in: International journal of rheumatic diseases Vol. 21; no. 1; pp. 179 - 185
• Main Authors: Zhang, Ming‐Yue, Yang, Xiao‐Ke, Lv, Tian‐Tian, Wu, Jun, Xu, Shu‐Zhen, Wang, Jie‐Bing, Pan, Hai‐Feng, Ye, Dong‐Qing
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.01.2018
• Subjects: Arthritis, Rheumatoid - diagnosis; Arthritis, Rheumatoid - ethnology; Arthritis, Rheumatoid - genetics; Asian Continental Ancestry Group - genetics; Case-Control Studies; Chi-Square Distribution; Ethnicity; European Continental Ancestry Group - genetics; Gene polymorphism; Genetic Association Studies; Genetic Predisposition to Disease; Humans; Linear Models; Lupus; Lupus Erythematosus, Systemic - diagnosis; Lupus Erythematosus, Systemic - ethnology; Lupus Erythematosus, Systemic - genetics; Meta-analysis; Minority & ethnic groups; Odds Ratio; Phenotype; Polymorphism; Polymorphism, Single Nucleotide; Rheumatoid arthritis; Risk Factors; Systemic lupus erythematosus; X-ray Repair Cross Complementing Protein 1 - genetics; XRCC1 protein; X‐ray repair cross‐complementation group 1; meta-analysis; systemic lupus erythematosus; X-ray repair cross-complementation group 1; polymorphism; rheumatoid arthritis
• ISSN: 1756-1841; 1756-185X; 1756-185X
• DOI: 10.1111/1756-185X.12966

Objective To determine whether X‐ray repair cross‐complementing group 1 (XRCC1) gene polymorphisms confer susceptibility to systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). A meta‐analysis was conducted to determine the associations between XRCC1 gene polymorphisms and susceptibility to SLE and RA. Methods A systematic literature search was conducted to identify all relevant studies. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were used to estimate the strength of the association. Results A total of nine case‐control articles, consisting of five SLE and four RA articles, involving 1138 patients and 1399 healthy controls, were included in the meta‐analysis. This meta‐analysis showed no significant association of the Arg399Gln and Arg194Trp polymorphisms with SLE were found in all models when all study subjects were considered together. Stratification by ethnicity indicated the variant Arg399 (A) allele carriers increased the risk of SLE in Asians (A vs. G: OR = 1.402, 95% CI = 1.139–1.726, P = 0.001) and decreased the risk of SLE in Caucasians (A vs. G: OR = 0.769, 95% CI = 0.630–0.937, P = 0.009; AA vs. AG+GG: OR = 0.727, 95% CI = 0.554–0.953, P = 0.021). However, we failed to reveal any association between XRCC1 gene polymorphisms (Arg399Gln, Arg280His and Arg194Trp) and RA risk under all analysis models. Similar results were obtained in the subgroup analysis based on ethnicity. Conclusions The present study suggests that the XRCC1 Arg399Gln polymorphism might be associated with genetic susceptibility to SLE in Asians and Caucasians, and there is no significant association between XRCC1 gene polymorphisms (Arg399Gln, Arg280His and Arg194Trp) and RA risk.