P2X7 Blockade Attenuates Murine Lupus Nephritis by Inhibiting Activation of the NLRP3/ASC/Caspase 1 Pathway

• Published in: Arthritis & rheumatology (Hoboken, N.J.) Vol. 65; no. 12; pp. 3176 - 3185
• Main Authors: Zhao, Jijun, Wang, Hongyue, Dai, Chao, Wang, Hongyang, Zhang, Hui, Huang, Yuefang, Wang, Shuang, Gaskin, Felicia, Yang, Niansheng, Man Fu, Shu
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.12.2013
• Subjects: Animals; Apoptosis Regulatory Proteins; CARD Signaling Adaptor Proteins; Carrier Proteins - metabolism; Caspase 1 - metabolism; Cytoskeletal Proteins - metabolism; Female; Inflammasomes - metabolism; Kidney - drug effects; Kidney - metabolism; Longevity - drug effects; Lupus; Lupus Nephritis - drug therapy; Lupus Nephritis - metabolism; Medical research; Mice; NLR Family, Pyrin Domain-Containing 3 Protein; Purinergic P2 Receptor Antagonists - pharmacology; Purinergic P2 Receptor Antagonists - therapeutic use; Receptors, Purinergic P2X7 - metabolism; Rodents; Rosaniline Dyes - pharmacology; Rosaniline Dyes - therapeutic use; Severity of Illness Index; Signal Transduction - drug effects

Objective The NLRP3 inflammasome plays key roles in inflammation and autoimmunity, and purinergic receptor P2X7 has been proposed to be upstream of NLRP3 activation. The aim of the present study, using murine models, was to investigate whether the P2X7/NLRP3 inflammasome pathway contributes to the p...