Monocyte–macrophage polarization balance in pre-diabetic individuals

• Published in: Acta diabetologica Vol. 50; no. 6; pp. 977 - 982
• Main Authors: Fadini, Gian Paolo, Cappellari, Roberta, Mazzucato, Marta, Agostini, Carlo, Vigili de Kreutzenberg, Saula, Avogaro, Angelo
• Format: Journal Article
• Language: English
• Published: Milan Springer Milan 01.12.2013; Springer Nature B.V
• Subjects: Antigens, CD - blood; Antigens, Differentiation, Myelomonocytic - blood; Atherosclerosis; Blood Cell Count; Cardiovascular disease; Cardiovascular Diseases - blood; Cardiovascular Diseases - immunology; Cell Polarity - immunology; Diabetes; Female; Flow Cytometry; Humans; Immunity (Disease); Inflammation - blood; Inflammation - immunology; Internal Medicine; Lipopolysaccharide Receptors - blood; Macrophage Activation; Macrophages - immunology; Male; Medicine; Medicine & Public Health; Metabolic Diseases; Middle Aged; Monocytes - immunology; Original Article; Prediabetic State - blood; Prediabetic State - immunology; Receptors, IgG - blood; Risk Factors; Studies; Italy; Innate immunity; Atherosclerosis; Diabetes

Pre-diabetes is characterized by increased cardiovascular risk and chronic inflammation. The activation of monocyte–macrophages plays major roles in vascular biology. Herein, we aimed to analyze monocyte–macrophage polarization status in subjects with IFG and/or IGT compared with normal glucose tole...