Association of Interleukin-23 Receptor Gene Single Nucleotide Polymorphisms with Ankylosing Spondylitis

It has been shown previously that the IL-23 receptor (IL-23R) variants are associated with ankylosing spondylitis (AS). It is unknown whether IL-23R is associated with AS in the Chinese population. The present study was performed to examine the association of IL-23R gene polymorphisms with susceptib...

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Published inAnnals of clinical and laboratory science Vol. 46; no. 5; pp. 470 - 473
Main Authors Su, Song-Sen, Wang, Su-Li, Lu, Liang-Jing, Lin, Ling
Format Journal Article
LanguageEnglish
Published United States 01.09.2016
Subjects
Adult
Alleles
Case-Control Studies
Cohort Studies
Female
Gene Frequency
Genetic Association Studies
Genetic Predisposition to Disease
Genotype
Humans
Male
Odds Ratio
Polymorphism, Single Nucleotide - genetics
Receptors, Interleukin - genetics
Spondylitis, Ankylosing - genetics
IL-23R
genetics
ankylosing spondylitis
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Summary:It has been shown previously that the IL-23 receptor (IL-23R) variants are associated with ankylosing spondylitis (AS). It is unknown whether IL-23R is associated with AS in the Chinese population. The present study was performed to examine the association of IL-23R gene polymorphisms with susceptibility to AS in the Chinese population. A total of 157 Chinese Han patients with AS and 150 ethnically matched healthy controls were enrolled. All patients were diagnosed with AS according to the modified New York criteria. 8 single nucleotide polymorphisms (SNPs) of the IL-23R gene cluster were genotyped. None of the 8 IL-23R SNPs were found to be associated with AS in the Chinese population. The association of IL-23R and AS that is seen in Caucasian patients with AS is not present in Chinese patients with AS.
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ISSN:1550-8080