Simultaneous 3D aortic lumen and vessel wall imaging at 0.55 T at either systole or diastole

• Published in: Magnetic resonance in medicine Vol. 94; no. 5; pp. 1982 - 1996
• Main Authors: Paredes, Matias, Castillo‐Passi, Carlos, Kunze, Karl P., Fotaki, Anastasia, Littlewood, Simon, Botnar, René M., Prieto, Claudia
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.11.2025
• Subjects: Adiabatic; Adiabatic flow; Adult; Algorithms; Aorta; Aorta - diagnostic imaging; aortic MRI; Blood; Blood vessels; bright and black blood; Cardiovascular diseases; Diameters; Diastole; Feasibility Studies; Female; free‐breathing; Humans; Image acquisition; Image Interpretation, Computer-Assisted - methods; Image Processing, Computer-Assisted - methods; Image quality; Imaging, Three-Dimensional - methods; low‐field; lumen; Magnetic Resonance Angiography - methods; Male; Medical imaging; Middle Aged; Myocardium; Phantoms, Imaging; Systole; systole and diastole; vessel wall; vessel wall; free‐breathing; lumen; aortic MRI; systole and diastole; low‐field; bright and black blood
• DOI: 10.1002/mrm.30611
• ISSN: 0740-3194; 1522-2594

Purpose To evaluate the feasibility of a novel, non‐contrast enhanced, 3D, simultaneous bright‐blood, and black‐blood sequence (iT2prep‐BOOST) for aortic imaging at 0.55 T at either systole or diastole. Methods Simultaneous contrast‐free 3D aortic lumen and vessel wall imaging at 0.55 T is achieved using the recently introduced iT2prep‐BOOST framework that interleaves the acquisition of two bright blood images (with inversion recovery T2 preparation [T2prep‐IR] and no preparation). To enable either systolic or diastolic aortic imaging, three T2 preparation pulses were investigated—an adiabatic RF pulse and two Malcolm‐Levitt (MLEV) pulses (MLEV4 and MLEV8)—to improve image quality in regions with high flow and susceptibility. The proposed approach was evaluated in phantom, 10 healthy subjects and 3 patients with suspected cardiovascular disease. Bright‐ and black‐blood images resulting from the three different T2 preparation pulses were compared both qualitatively and quantitatively, using a 4‐point Likert scale for vessel sharpness and presence of blood artifacts. Additionally, the contrast ratio between the lumen and myocardium was computed. Aortic measurements, including the aortic annulus area at systole and diastole, cusp‐commissure measurement at the aortic root level during diastole, and aortic diameter at the ascending aortic level during diastole were also performed. Results Excellent or good image quality scores were obtained for both bright‐ and black‐blood images with iT2prep‐BOOST at 0.55 T with all three preparation pulses. The use of MLEV8 T2 preparation scheme improves systolic image quality, reducing the presence of artifacts with a significant difference (p < 0.05) at the mid descending aorta level. This scheme also increases the contrast ratio between aortic lumen and myocardium, compared to the previously used adiabatic RF T2 preparation. The aortic root diameter and area were consistent with values reported in the literature for healthy subjects at 1.5 T. Conclusion The feasibility of a novel, non‐contrast‐enhanced, 3D aortic imaging framework for simultaneous bright‐blood and black‐blood imaging was demonstrated at 0.55 T for either systole or diastole, with a scan time of 7 min. Good image quality scores and aortic measurements in agreement with literature values at 1.5 T were achieved with the MLEV8 T2 preparation. Studies in a larger cohort of healthy subjects and patients with aortopathies are warranted.