Possible improvement in uteroplacental blood flow during atrial natriuretic peptide infusion in preeclampsia

• Published in: Obstetrics and gynecology (New York. 1953) Vol. 84; no. 2; p. 235
• Main Authors: Grunewald, C, Nisell, H, Jansson, T, Kublickas, M, Thornström, S, Nylund, L
• Format: Journal Article
• Language: English
• Published: United States 01.08.1994
• Subjects: Adult; Atrial Natriuretic Factor - administration & dosage; Blood Flow Velocity - drug effects; Blood Flow Velocity - physiology; Blood Pressure - drug effects; Blood Pressure - physiology; Female; Guanosine Monophosphate - blood; Humans; Indium Radioisotopes; Infusions, Intravenous; Maternal-Fetal Exchange - drug effects; Maternal-Fetal Exchange - physiology; Placenta - blood supply; Placenta - diagnostic imaging; Pre-Eclampsia - blood; Pre-Eclampsia - drug therapy; Pre-Eclampsia - physiopathology; Pregnancy; Pulsatile Flow; Radionuclide Imaging; Regional Blood Flow - drug effects; Regional Blood Flow - physiology; Ultrasonography, Prenatal; Uterus - blood supply; Uterus - diagnostic imaging; Vasodilation - drug effects; Vasodilation - physiology

To study the effects of low doses of the hormone atrial natriuretic peptide (ANP) on uteroplacental blood flow in patients with preeclampsia. Eleven women with preeclampsia were infused intravenously with ANP (10 ng/kg/minute). Uteroplacental blood flow index was measured using dynamic placental sci...