PTPN3 acts as a tumor suppressor and boosts TGF‐β signaling independent of its phosphatase activity

• Published in: The EMBO journal Vol. 38; no. 14; pp. e99945 - n/a
• Main Authors: Yuan, Bo, Liu, Jinquan, Cao, Jin, Yu, Yi, Zhang, Hanchenxi, Wang, Fei, Zhu, Yezhang, Xiao, Mu, Liu, Sisi, Ye, Youqiong, Ma, Le, Xu, Dewei, Xu, Ningyi, Li, Yi, Zhao, Bin, Xu, Pinglong, Jin, Jianping, Xu, Jianming, Chen, Xi, Shen, Li, Lin, Xia, Feng, Xin‐Hua
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 15.07.2019; Springer Nature B.V
• Subjects: Amino acid substitution; Amino acids; Arginine; Cancer; Cholangiocarcinoma; EMBO03; EMBO31; EMBO37; Hepatocellular carcinoma; Kinases; Leucine; Mutation; Pathogenesis; Phosphatase; Phosphorylation; Physiological responses; Physiology; Protein-tyrosine-phosphatase; Signaling; Smad protein; Smurf2; TGF‐β signaling; Transcription; Tumor suppressor genes; Tumors; Tyrosine; TβRI; TβRI; phosphatase; Smurf2; cholangiocarcinoma; TGF‐β signaling

TGF‐β controls a variety of cellular functions during development. Abnormal TGF‐β responses are commonly found in human diseases such as cancer, suggesting that TGF‐β signaling must be tightly regulated. Here, we report that protein tyrosine phosphatase non‐receptor 3 (PTPN3) profoundly potentiates...