H2A.Z and H2B.Z double‐variant nucleosomes define intergenic regions and dynamically occupy var gene promoters in the malaria parasite Plasmodium falciparum

• Published in: Molecular microbiology Vol. 87; no. 6; pp. 1167 - 1182
• Main Authors: Petter, Michaela, Selvarajah, Shamista A., Lee, Chin Chin, Chin, Wai Hoe, Gupta, Archna P., Bozdech, Zbynek, Brown, Graham V., Duffy, Michael F.
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.03.2013
• Subjects: Bacterial proteins; DNA, Intergenic; Erythrocytes; Gene expression; Gene Expression Regulation; Genes; Histones - metabolism; Malaria; Nucleosomes - metabolism; Parasites; Parasitic protozoa; Plasmodium falciparum - genetics; Plasmodium falciparum - pathogenicity; Promoter Regions, Genetic; Protein Binding; Protein Multimerization; Protozoan Proteins - biosynthesis; Vector-borne diseases; Virology; Virulence

Summary Histone variants are important components of eukaryotic chromatin and can alter chromatin structure to confer specialized functions. H2B variant histones are rare in nature but have evolved independently in the phyla Apicomplexa and Trypanasomatida. Here, we investigate the apicomplexan‐spec...