Constant Enzymatic in situ Production of H2O2 for an Unspecific Peroxygenase by an l–Amino Acid Oxidase

• Published in: Advanced synthesis & catalysis Vol. 367; no. 11
• Main Authors: Last, Simon, Heinks, Tobias, Dietz, Niklas, Koopmeiners, Simon, Fischer von Mollard, Gabriele, Weissenborn, Martin J., Langermann, Jan
• Format: Journal Article
• Language: English
• Published: Heidelberg Wiley Subscription Services, Inc 03.06.2025
• Subjects: Amino acid oxidase; Amino acids; Enzyme cascade; Enzyme stability; Hydrogen peroxide; Hydroxylation; Oxyfunctionalisation; Unspecific Peroxygenases (UPO)

Unspecific Peroxygenases have been the subject of a lot of research in the recent past as they offer opportunities for green hydroxylation reactions using hydrogen peroxide (H2O2) as donor. A striking problem of UPOs is their low stability against their own co‐substrate H2O2. In order to prevent the...