Quantitative distribution of a panel of circulating mRNA in preeclampsia versus controls
Objective The aim of this study was to evaluate whether the quantitative distribution of a panel of circulating mRNAs from maternal whole blood of normal pregnancies is statistically different from those complicated with preeclampsia (PE) with or without intrauterine growth restriction (IUGR). Metho...
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Published in | Prenatal diagnosis Vol. 26; no. 12; pp. 1115 - 1120 |
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Main Authors | , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Chichester, UK
John Wiley & Sons, Ltd
01.12.2006
Wiley |
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Abstract | Objective
The aim of this study was to evaluate whether the quantitative distribution of a panel of circulating mRNAs from maternal whole blood of normal pregnancies is statistically different from those complicated with preeclampsia (PE) with or without intrauterine growth restriction (IUGR).
Methods
Maternal whole blood of six subjects with mild or severe PE with or without IUGR and 30 matched controls (1:5 match for gestational age) were retrospectively examined for circulating mRNA markers. Seven specific mRNA markers were identified and chosen based on previous microarray mRNA expressions performed on placental tissue from normal and PE patients. They were human placental lactogen (hPL), inhibin A, KISS‐1, pregnancy‐associated plasma protein‐A (PAPP‐A), plasminogen activator inhibitor type 1 (PAI‐1), selectin‐P and vascular endothelial growth factor receptor (VEGFR), which were therefore quantified for statistical purposes.
Results
Median gestational age was 229 (178–283) and 232 (194–262) days for controls and cases respectively. All mRNA markers but PAPP‐A, showed statistically different median values. They were hPL, inhibin A, KISS‐1, PAI‐1, Selectin‐P, and VEGFR. Inhibin A, Selectin‐P and VEGFR showed higher values than expected for controls. Instead, hPL, KISS‐1 and PAI‐1 values of PE patients were lower than those of controls. Selectin‐P was the marker with the most aberrant difference, followed by VEGFR and KISS‐1.
Conclusion
This preliminary analysis revealed that the median values of a panel of mRNAs from the maternal blood of PE patients were different from those of the same gestational age control group at the third trimester. If prospective studies at the second trimester could detect a related marker sufficiently able to discriminate between affected and unaffected patients and thus detect the disease before its clinical onset, then a screening project using a panel of mRNAs would be feasible. Copyright © 2006 John Wiley & Sons, Ltd. |
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AbstractList | Objective
The aim of this study was to evaluate whether the quantitative distribution of a panel of circulating mRNAs from maternal whole blood of normal pregnancies is statistically different from those complicated with preeclampsia (PE) with or without intrauterine growth restriction (IUGR).
Methods
Maternal whole blood of six subjects with mild or severe PE with or without IUGR and 30 matched controls (1:5 match for gestational age) were retrospectively examined for circulating mRNA markers. Seven specific mRNA markers were identified and chosen based on previous microarray mRNA expressions performed on placental tissue from normal and PE patients. They were human placental lactogen (hPL), inhibin A, KISS‐1, pregnancy‐associated plasma protein‐A (PAPP‐A), plasminogen activator inhibitor type 1 (PAI‐1), selectin‐P and vascular endothelial growth factor receptor (VEGFR), which were therefore quantified for statistical purposes.
Results
Median gestational age was 229 (178–283) and 232 (194–262) days for controls and cases respectively. All mRNA markers but PAPP‐A, showed statistically different median values. They were hPL, inhibin A, KISS‐1, PAI‐1, Selectin‐P, and VEGFR. Inhibin A, Selectin‐P and VEGFR showed higher values than expected for controls. Instead, hPL, KISS‐1 and PAI‐1 values of PE patients were lower than those of controls. Selectin‐P was the marker with the most aberrant difference, followed by VEGFR and KISS‐1.
Conclusion
This preliminary analysis revealed that the median values of a panel of mRNAs from the maternal blood of PE patients were different from those of the same gestational age control group at the third trimester. If prospective studies at the second trimester could detect a related marker sufficiently able to discriminate between affected and unaffected patients and thus detect the disease before its clinical onset, then a screening project using a panel of mRNAs would be feasible. Copyright © 2006 John Wiley & Sons, Ltd. The aim of this study was to evaluate whether the quantitative distribution of a panel of circulating mRNAs from maternal whole blood of normal pregnancies is statistically different from those complicated with preeclampsia (PE) with or without intrauterine growth restriction (IUGR). Maternal whole blood of six subjects with mild or severe PE with or without IUGR and 30 matched controls (1:5 match for gestational age) were retrospectively examined for circulating mRNA markers. Seven specific mRNA markers were identified and chosen based on previous microarray mRNA expressions performed on placental tissue from normal and PE patients. They were human placental lactogen (hPL), inhibin A, KISS-1, pregnancy-associated plasma protein-A (PAPP-A), plasminogen activator inhibitor type 1 (PAI-1), selectin-P and vascular endothelial growth factor receptor (VEGFR), which were therefore quantified for statistical purposes. Median gestational age was 229 (178-283) and 232 (194-262) days for controls and cases respectively. All mRNA markers but PAPP-A, showed statistically different median values. They were hPL, inhibin A, KISS-1, PAI-1, Selectin-P, and VEGFR. Inhibin A, Selectin-P and VEGFR showed higher values than expected for controls. Instead, hPL, KISS-1 and PAI-1 values of PE patients were lower than those of controls. Selectin-P was the marker with the most aberrant difference, followed by VEGFR and KISS-1. This preliminary analysis revealed that the median values of a panel of mRNAs from the maternal blood of PE patients were different from those of the same gestational age control group at the third trimester. If prospective studies at the second trimester could detect a related marker sufficiently able to discriminate between affected and unaffected patients and thus detect the disease before its clinical onset, then a screening project using a panel of mRNAs would be feasible. OBJECTIVEThe aim of this study was to evaluate whether the quantitative distribution of a panel of circulating mRNAs from maternal whole blood of normal pregnancies is statistically different from those complicated with preeclampsia (PE) with or without intrauterine growth restriction (IUGR).METHODSMaternal whole blood of six subjects with mild or severe PE with or without IUGR and 30 matched controls (1:5 match for gestational age) were retrospectively examined for circulating mRNA markers. Seven specific mRNA markers were identified and chosen based on previous microarray mRNA expressions performed on placental tissue from normal and PE patients. They were human placental lactogen (hPL), inhibin A, KISS-1, pregnancy-associated plasma protein-A (PAPP-A), plasminogen activator inhibitor type 1 (PAI-1), selectin-P and vascular endothelial growth factor receptor (VEGFR), which were therefore quantified for statistical purposes.RESULTSMedian gestational age was 229 (178-283) and 232 (194-262) days for controls and cases respectively. All mRNA markers but PAPP-A, showed statistically different median values. They were hPL, inhibin A, KISS-1, PAI-1, Selectin-P, and VEGFR. Inhibin A, Selectin-P and VEGFR showed higher values than expected for controls. Instead, hPL, KISS-1 and PAI-1 values of PE patients were lower than those of controls. Selectin-P was the marker with the most aberrant difference, followed by VEGFR and KISS-1.CONCLUSIONThis preliminary analysis revealed that the median values of a panel of mRNAs from the maternal blood of PE patients were different from those of the same gestational age control group at the third trimester. If prospective studies at the second trimester could detect a related marker sufficiently able to discriminate between affected and unaffected patients and thus detect the disease before its clinical onset, then a screening project using a panel of mRNAs would be feasible. |
Author | Purwosunu, Yuditiya Rizzo, Nicola Morano, Danila Sekizawa, Akihiko Concu, Manuela Farina, Antonio Banzola, Irina Giommi, Federica Carinci, Paolo Mabrook, Mohamad Bevini, Maurizio Okai, Takashi |
Author_xml | – sequence: 1 givenname: Antonio surname: Farina fullname: Farina, Antonio email: antonio.farina@unibo.it – sequence: 2 givenname: Akihiko surname: Sekizawa fullname: Sekizawa, Akihiko – sequence: 3 givenname: Yuditiya surname: Purwosunu fullname: Purwosunu, Yuditiya – sequence: 4 givenname: Nicola surname: Rizzo fullname: Rizzo, Nicola – sequence: 5 givenname: Irina surname: Banzola fullname: Banzola, Irina – sequence: 6 givenname: Manuela surname: Concu fullname: Concu, Manuela – sequence: 7 givenname: Danila surname: Morano fullname: Morano, Danila – sequence: 8 givenname: Federica surname: Giommi fullname: Giommi, Federica – sequence: 9 givenname: Maurizio surname: Bevini fullname: Bevini, Maurizio – sequence: 10 givenname: Mohamad surname: Mabrook fullname: Mabrook, Mohamad – sequence: 11 givenname: Paolo surname: Carinci fullname: Carinci, Paolo – sequence: 12 givenname: Takashi surname: Okai fullname: Okai, Takashi |
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Keywords | multivariable screening Pregnancy disorders Genetic marker Prenatal Diagnosis Molecular marker real-time PCR Medical screening Real time circulating mRNA Pregnancy toxemia Polymerase chain reaction Messenger RNA Preeclampsia Distribution Molecular biology molecular markers Comparative study Quantitative analysis |
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References_xml | – volume: 161 start-page: 432 issue: 2 year: 1989 end-page: 436 article-title: Predictive value of increased plasma levels of fibronectin in gestational hypertension publication-title: Am J Obstet Gynecol – volume: 185 start-page: 781 issue: 4 year: 2001 end-page: 785 article-title: Elevated plasma homocysteine in early pregnancy: a risk factor for the development of severe preeclampsia publication-title: Am J Obstet Gynecol – volume: 293 start-page: 77 issue: 1 year: 2005 end-page: 85 article-title: Urinary placental growth factor and risk of preeclampsia publication-title: JAMA – volume: 23 start-page: 45 issue: 1 year: 1999 end-page: 57 article-title: Prediction of preeclampsia publication-title: Semin Perinatol – volume: 2 start-page: 39 issue: 1 year: 2002 end-page: 43 article-title: Correlation of P‐selectin and lipoprotein(a), and other lipid parameters in preeclampsia publication-title: Clin Exp Med – volume: 61 start-page: 20 issue: 1 year: 1989 end-page: 26 article-title: Plasminogen activator inhibitor types 1 and 2 in human trophoblasts. PAI‐1 is an immunocytochemical marker of invading trophoblasts publication-title: Lab Invest – volume: 55 start-page: 9 issue: 1 year: 2006 end-page: 15 article-title: Increased plasma mRnas of placenta‐specific 1 (PLAC1) and glial cells‐missing 1 (GCM1) in mothers with pre‐eclampsia publication-title: Hiroshima J Med Sci – volume: 80 start-page: 1046 issue: 12 year: 1973 end-page: 1053 article-title: Human placental lactogen (HPL) levels in abnormal pregnancies publication-title: J Obstet Gynaecol Br Commonw – volume: 50 start-page: 221 issue: 1 year: 2004 end-page: 224 article-title: Proteinuria and hypertension are independent factors affecting fetal DNA values: a retrospective analysis of affected and unaffected patients publication-title: Clin Chem – volume: 56 start-page: 103 issue: 1–2 year: 1996 end-page: 116 article-title: Embryo implantation in mouse: fetomaternal coordination in the pattern of expression of uPA, uPAR, PAI‐1 and alpha 2MR/LRP genes publication-title: Mech Dev – volume: 15 start-page: 1640 issue: 7 year: 2000 end-page: 1645 article-title: Serum inhibin A and activin A are elevated prior to the onset of pre‐eclampsia publication-title: Hum Reprod – volume: 2 start-page: 114 year: 1976 end-page: 142 article-title: Human placental lactogen publication-title: Contrib Gynecol Obstet – volume: 23 start-page: 413 issue: 2 year: 2003 end-page: 442 article-title: Prenatal screening, epidemiology, diagnosis, and management of preeclampsia publication-title: Clin Lab Med – volume: 259 start-page: 9121 issue: 14 year: 1984 end-page: 9126 article-title: A platelet membrane protein expressed during platelet activation and secretion. Studies using a monoclonal antibody specific for thrombin‐activated platelets publication-title: J Biol Chem – volume: 107 start-page: 196 issue: 2 year: 2000 end-page: 208 article-title: How useful is uterine artery Doppler flow velocimetry in the prediction of pre‐eclampsia, intrauterine growth retardation and perinatal death? An overview publication-title: BJOG – volume: 181 start-page: 975 issue: 4 year: 1999 end-page: 980 article-title: Preeclampsia and genetic risk factors for thrombosis: a case‐control study publication-title: Am J Obstet Gynecol – volume: 182 start-page: 321 issue: 2 year: 2000 end-page: 325 article-title: Altered circulating levels of adhesion molecules at 18 weeks' gestation among women with eventual preeclampsia: indicators of disturbed placentation in absence of evidence of endothelial dysfunction? publication-title: Am J Obstet Gynecol – volume: 79 start-page: 500 issue: 3 year: 1998 end-page: 508 article-title: Abnormal expression of type 1 plasminogen activator inhibitor and tissue factor in severe preeclampsia publication-title: Thromb Haemost – volume: 55 start-page: 830 issue: 8 year: 2003 end-page: 837 article-title: Detection of the damage of placental villous trophoblasts and the possible pathogenesis of preeclampsia publication-title: Acta Obstet Gynaecol Jpn – volume: 117 start-page: 1319 issue: Pt 8 year: 2004 end-page: 1328 article-title: Kisspeptin‐10, a KiSS‐1/metastin‐derived decapeptide, is a physiological invasion inhibitor of primary human trophoblasts publication-title: J Cell Sci – volume: 8 start-page: 65 issue: 2 year: 2001 end-page: 68 article-title: Multiple marker second trimester serum screening for pre‐eclampsia publication-title: J Med Screen – volume: 184 start-page: 146 issue: 2 year: 2001b end-page: 152 article-title: Maternal plasma vascular endothelial growth factor concentrations in normal and hypertensive pregnancies and their relationship to peripheral vascular resistance publication-title: Am J Obstet Gynecol – volume: 356 start-page: 1260 issue: 9237 year: 2000 end-page: 1265 article-title: Pre‐eclampsia publication-title: Lancet – volume: 47 start-page: 137 issue: 1 year: 2001 end-page: 139 article-title: Increased maternal plasma fetal DNA concentrations in women who eventually develop preeclampsia publication-title: Clin Chem – volume: 17 start-page: 584 issue: 6 year: 2005 end-page: 590 article-title: Uterine artery Doppler screening for adverse pregnancy outcome publication-title: Curr Opin Obstet Gynecol – volume: 108 start-page: 709 issue: 7 year: 2001a end-page: 715 article-title: Plasma P‐selectin is elevated in the first trimester in women who subsequently develop pre‐eclampsia publication-title: BJOG – volume: 45 start-page: 184 issue: 2 year: 1999 end-page: 188 article-title: Quantitative abnormalities of fetal DNA in maternal serum in preeclampsia publication-title: Clin Chem – volume: 85 start-page: 839 issue: 12 year: 2005 end-page: 842 article-title: The role of KiSS‐1 and matrix metalloproteinase‐9 in regulation of invasion of trophoblasts publication-title: Zhonghua Yi Xue Za Zhi – volume: 17 start-page: 477 issue: 6 year: 2001 end-page: 484 article-title: Improved early prediction of pre‐eclampsia by combining second‐trimester maternal serum inhibin‐A and uterine artery Doppler publication-title: Ultrasound Obstet Gynecol – volume: 101 start-page: 488 issue: 6 year: 1994 end-page: 492 article-title: Haemostatic, fibrinolytic and endothelial variables in normal pregnancies and pre‐eclampsia publication-title: Br J Obstet Gynaecol – volume: 17 start-page: 3 issue: 1 year: 2005 end-page: 18 article-title: Plasma soluble vascular endothelial growth factor receptor‐1 concentration is elevated prior to the clinical diagnosis of pre‐eclampsia publication-title: J Matern Fetal Neonatal Med – volume: 280 start-page: 671 issue: 6215 year: 1980 end-page: 673 article-title: Assay of a placental protein to determine fetal risk publication-title: Br Med J – volume: 9 start-page: 87 year: 1989 end-page: 115 article-title: Type 1 plasminogen activator inhibitor publication-title: Prog Hemost Thromb – volume: 168 start-page: 346 issue: 2 year: 1996 end-page: 353 article-title: Hypoxia impairs cell fusion and differentiation process in human cytotrophoblast, in vitro publication-title: J Cell Physiol – volume: 21 start-page: 487 issue: 5–6 year: 2000 end-page: 492 article-title: Correlation between second trimester maternal serum inhibin‐A and human chorionic gonadotrophin for the prediction of pre‐eclampsia publication-title: Placenta – volume: 8 start-page: 1640 issue: 10 year: 1993 end-page: 1644 article-title: The possible involvement of tissue type plasminogen activator in luteolysis of rhesus monkey publication-title: Hum Reprod – volume: 24 start-page: 722 issue: 9 year: 2004a end-page: 726 article-title: Total cell‐free DNA (beta‐globin gene) distribution in maternal plasma at the second trimester: a new prospective for preeclampsia screening publication-title: Prenat Diagn – volume: 174 start-page: 272 issue: 1 Pt 1 year: 1996 end-page: 277 article-title: Plasma P selectin (GMP‐140) and glycocalicin are elevated in preeclampsia and eclampsia: their significances publication-title: Am J Obstet Gynecol – volume: 37 start-page: 2126 issue: 5 year: 1996 end-page: 2132 article-title: Coordinated expression of tissue‐type plasminogen activator and plasminogen activator inhibitor type 1 during corpus luteum formation and luteolysis in the adult pseudopregnant rat publication-title: Endocrinology – volume: 7 start-page: 170 issue: 3 year: 2000 end-page: 174 article-title: Second‐trimester levels of maternal serum human chorionic gonadotropin and inhibin a as predictors of preeclampsia in the third trimester of pregnancy publication-title: J Soc Gynecol Investig – volume: 72 start-page: 1 issue: 1 year: 1997 end-page: 22 article-title: The urokinase‐type plasminogen activator system in cancer metastasis: a review publication-title: Int J Cancer – volume: 104 start-page: 1367 issue: 6 year: 2004 end-page: 1391 article-title: World Health Organization systematic review of screening tests for preeclampsia publication-title: Obstet Gynecol – volume: 175 start-page: 1147 issue: 4 year: 1992 end-page: 1150 article-title: Characterization of GMP‐140 (P‐selectin) as a circulating plasma protein publication-title: J Exp Med – volume: 22 start-page: 45 issue: 1 year: 2003 end-page: 55 article-title: Women with preeclampsia have increased serum levels of pregnancy‐associated plasma protein A (PAPP‐A), inhibin A, activin A and soluble E‐selectin publication-title: Hypertens Pregnancy – volume: 50 start-page: 1851 issue: 10 year: 2004b end-page: 1854 article-title: Circulating corticotropin‐releasing hormone mRNA in maternal plasma: relationship with gestational age and severity of preeclampsia publication-title: Clin Chem – volume: 41 start-page: 461 issue: 6 year: 2004 end-page: 467 article-title: Systematic micro‐array based identification of placental mRNA in maternal plasma: towards non‐invasive prenatal gene expression profiling publication-title: J Med Genet |
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The aim of this study was to evaluate whether the quantitative distribution of a panel of circulating mRNAs from maternal whole blood of normal... The aim of this study was to evaluate whether the quantitative distribution of a panel of circulating mRNAs from maternal whole blood of normal pregnancies is... OBJECTIVEThe aim of this study was to evaluate whether the quantitative distribution of a panel of circulating mRNAs from maternal whole blood of normal... |
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SubjectTerms | Biological and medical sciences Biomarkers - blood Case-Control Studies circulating mRNA Diseases of mother, fetus and pregnancy Female Fetal Growth Retardation - genetics Gestational Age Gynecology. Andrology. Obstetrics Humans Inhibins - genetics Kisspeptins Management. Prenatal diagnosis Medical sciences molecular markers multivariable screening P-Selectin - genetics Placental Lactogen - genetics Plasminogen Activator Inhibitor 1 - genetics Pre-Eclampsia - genetics preeclampsia Pregnancy Pregnancy Trimester, Third Pregnancy-Associated Plasma Protein-A - genetics Pregnancy. Fetus. Placenta real‐time PCR Receptors, Vascular Endothelial Growth Factor - genetics Reference Values RNA, Messenger - blood Tumor Suppressor Proteins - genetics |
Title | Quantitative distribution of a panel of circulating mRNA in preeclampsia versus controls |
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