Anticancer Activity of Branched-chain Derivatives of Oleic Acid

• Published in: Anticancer research Vol. 31; no. 10; pp. 3165 - 3169
• Main Authors: DAILEY, Oliver D, XI WANG, FENG CHEN, GUOHUI HUANG
• Format: Journal Article
• Language: English
• Published: Attiki International Institute of Anticancer Research 01.10.2011
• Subjects: alcohols; anticarcinogenic activity; Antineoplastic Agents; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Biological and medical sciences; branched chain fatty acids; breast neoplasms; Cell Line, Tumor; Cell Survival; Cell Survival - drug effects; chemistry; colorectal neoplasms; dimethyl sulfoxide; drug effects; Drug Screening Assays, Antitumor; Gynecology. Andrology. Obstetrics; human cell lines; Humans; Inhibitory Concentration 50; Mammary gland diseases; Medical sciences; oleic acid; Oleic Acid - chemistry; Oleic Acid - pharmacology; pharmacology; Tumors; Antineoplastic agent; Human; Breast disease; antitumor; MCF-7; Lipids; Breast cancer; Malignant tumor; Fatty acids; human colon cancer; Biological activity; anticancer; Colonic disease; Mammary gland diseases; Colon cancer; Cancerology; Oleic acid; HT-29; Established cell line; human breast cancer; Digestive diseases; Intestinal disease; Branched-chain fatty acids; Cancer

A number of unsaturated fatty acids and a few saturated branched-chain fatty acids have been reported to exhibit anticancer activity. In previously reported research, several novel branched-chain derivatives (methyl, n-butyl, phenyl) of methyl oleate were produced by bromination in the allylic posit...