LncRNA PCAT1 promotes metastasis of endometrial carcinoma through epigenetical downregulation of E-cadherin associated with methyltransferase EZH2

• Published in: Life sciences (1973) Vol. 243; p. 117295
• Main Authors: Zhang, Chunhua, Shao, Shasha, Zhang, Yujian, Wang, Liyang, Liu, Jianzhong, Fang, Fang, Li, Peiquan, Wang, Bo
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier BV 15.02.2020
• Subjects: Animals; Biotechnology; cadherins; Cadherins - physiology; carcinogenesis; Carcinoma; Cell Line, Tumor; Cell proliferation; Chemoradiotherapy; diagnostic techniques; Down-regulation; Down-Regulation - genetics; E-cadherin; Endometrial Neoplasms - enzymology; Endometrial Neoplasms - genetics; Endometrial Neoplasms - pathology; Endometrium; Enhancer of Zeste Homolog 2 Protein - metabolism; Epigenesis, Genetic; Female; genes; Histone methyltransferase; histones; Humans; Immunoprecipitation; Metastases; Metastasis; methyltransferases; Mice; Mice, Nude; Middle Aged; N-Cadherin; Neoplasm Metastasis - genetics; Non-coding RNA; Overexpression; Patients; precipitin tests; Protein Binding; RNA, Long Noncoding - metabolism; RNA, Long Noncoding - physiology; Surgery; Tumorigenesis; Uterine cancer; Vimentin; women; LncRNA PCAT1; Metastasis; E-cadherin; Endometrial carcinoma; EZH2

More than 140 thousands of women suffer from endometrial carcinoma in the worldwide, and over 40 thousand of the patients die before and after in surgery and chemoradiotherapy because of its metastasis. However, its molecular mechanism is much less known compared to other cancers. In this study, we...