Identification and evaluation of false-negative antibody screens

• Published in: Transfusion (Philadelphia, Pa.) Vol. 50; no. 3; pp. 617 - 621
• Main Authors: POWERS, Amy, CHANDRASHEKAR, Sarayu, MOHAMMED, Monique, UHL, Lynne
• Format: Journal Article
• Language: English
• Published: Hoboken, NJ Wiley 01.03.2010
• Subjects: Anesthesia; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Anesthesia: equipment, devices; Biological and medical sciences; Blood Banks; Blood Group Incompatibility - etiology; Blood Group Incompatibility - prevention & control; Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis; Erythrocytes; False Negative Reactions; Female; Hemolysis; Humans; Incidence; Isoantibodies - blood; Male; Medical sciences; Transfusion Reaction; Transfusions. Complications. Transfusion reactions. Cell and gene therapy; Medical screening; False negative; Transfusion

Non-ABO alloantibodies are frequently implicated in hemolytic transfusion reactions and are a leading cause of transfusion-related mortality. Detection of clinically significant non-ABO alloantibodies is reliant on an antibody screen, which is prone to clerical, technical, and reagent error. Data on...