BQ323636.1, a Novel Splice Variant to NCOR2, as a Predictor for Tamoxifen-Resistant Breast Cancer

• Published in: Clinical cancer research Vol. 24; no. 15; pp. 3681 - 3691
• Main Authors: Gong Chun, Man Ellen PS, Tsoi Ho, Lee Terence KW, Lee, Paul, Sai-Ting, Ma, Lai-San, Wong, Mai-Yee, Luk, Rakha, Emad A, Green, Andrew R, Ellis, Ian O, Lam, Eric W-F, Kwok-Leung, Cheung, Ui-Soon, Khoo
• Format: Journal Article
• Language: English
• Published: Philadelphia American Association for Cancer Research Inc 01.08.2018
• Subjects: Alternative splicing; Biomarkers; Breast cancer; Cancer; Design of experiments; DNA microarrays; Drug resistance; Epitopes; Estrogen receptors; Estrogens; Experimental design; Immunohistochemistry; In vivo methods and tests; Mathematical models; Metastases; Patients; Survival; Tamoxifen

Purpose: Adjuvant tamoxifen treatment revolutionized the management of estrogen receptor (ER)–positive breast cancers to prevent cancer recurrence; however, drug resistance compromises its clinical efficacy. The mechanisms underlying tamoxifen resistance are not fully understood, and no robust bioma...