Expression of vascular endothelial growth factor and hypoxia-inducible factor in the airway of asthmatic patients

• Published in: Annals of allergy, asthma, & immunology Vol. 97; no. 6; p. 794
• Main Authors: Lee, Sook Young, Kwon, Soon, Kim, Kwan Hyoung, Moon, Hwa Sik, Song, Jung Sup, Park, Sung Hak, Kim, Young Kyoon
• Format: Journal Article
• Language: English
• Published: United States 01.12.2006
• Subjects: Asthma - blood; Asthma - metabolism; Basic Helix-Loop-Helix Transcription Factors - metabolism; Bronchoalveolar Lavage Fluid - chemistry; Bronchoalveolar Lavage Fluid - cytology; Case-Control Studies; Eosinophils; Humans; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism; Leukocyte Count; Respiratory Mucosa - metabolism; Vascular Endothelial Growth Factor A - metabolism

Vascular endothelial growth factor (VEGF) is a potent proangiogenic cytokine, and it also increases vascular permeability. It is well known that VEGF levels are increased in the airway of asthmatic patients. Hypoxia-inducible factor (HIF) induces a rapid and strong increase in VEGF expression. To ev...