Immune responses and latent herpesvirus reactivation in spaceflight

• Published in: Aviation, space, and environmental medicine Vol. 72; no. 10; p. 884
• Main Authors: Stowe, R P, Mehta, S K, Ferrando, A A, Feeback, D L, Pierson, D L
• Format: Journal Article
• Language: English
• Published: United States 01.10.2001
• Subjects: Adult; Age Factors; Aged; Antibodies, Viral - analysis; Astronauts; Cytomegalovirus - immunology; Down-Regulation; Herpesviridae - immunology; Herpesviridae - isolation & purification; Humans; Hydrocortisone - blood; Immunity, Cellular; Lymphocyte Subsets; Middle Aged; Space Flight; Stress, Psychological - immunology; Virus Activation - physiology; Virus Latency - physiology; Virus Shedding - physiology; NASA Center JSC; NASA Discipline Regulatory Physiology; Non-NASA Center

Increased frequency and severity of herpesvirus infections are common in individuals with impaired cellular immunity, a phenomenon observed in both the elderly and astronauts alike. This study investigated immune responses and latent herpesvirus reactivation during a 9-d spaceflight. In addition, ad...