Nicotinamide mononucleotide (NMN) treatment attenuates oxidative stress and rescues angiogenic capacity in aged cerebromicrovascular endothelial cells: a potential mechanism for the prevention of vascular cognitive impairment

• Published in: GeroScience Vol. 41; no. 5; pp. 619 - 630
• Main Authors: Kiss, Tamas, Balasubramanian, Priya, Valcarcel-Ares, Marta Noa, Tarantini, Stefano, Yabluchanskiy, Andriy, Csipo, Tamas, Lipecz, Agnes, Reglodi, Dora, Zhang, Xin A., Bari, Ferenc, Farkas, Eszter, Csiszar, Anna, Ungvari, Zoltan
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.10.2019; Springer Nature B.V
• Subjects: Aging; Aging - physiology; Angiogenesis; Animals; Biomedical and Life Sciences; Brain - blood supply; Cell Biology; Cell Movement - physiology; Cell proliferation; Cell Proliferation - physiology; Cerebral blood flow; Cognitive ability; Cognitive Dysfunction - prevention & control; Dementia disorders; Endothelial cells; Endothelial Cells - physiology; Endothelium; Geriatrics; Geriatrics/Gerontology; Hydrogen peroxide; Hydrogen Peroxide - metabolism; Life Sciences; Microvessels - cytology; Molecular Medicine; NAD; Neovascularization, Physiologic - drug effects; Neovascularization, Physiologic - physiology; Nicotinamide; Nicotinamide Mononucleotide - pharmacology; Original; Original Article; Oxidative stress; Oxidative Stress - drug effects; Rats, Inbred BN; Rats, Inbred F344; SIRT1 protein; Vascular dementia; Vasodilation; Wound healing; NAD; Endothelial dysfunction; precursor; Microcirculation; Senescence; Vascular contributions to cognitive impairment and dementia; NAD+ precursor

Age-related impairment of angiogenesis likely has a critical role in cerebromicrovascular rarefaction and development of vascular cognitive impairment and dementia (VCID) in the elderly. Recently, we demonstrated that aging is associated with NAD + depletion in the vasculature and that administratio...