Monotherapy with LF 15-0195, an analogue of 15-deoxyspergualin, significantly prolongs renal allograft survival in monkeys

• Published in: Transplantation Vol. 75; no. 8; p. 1166
• Main Authors: Yang, Hongji, Chen, Gang, Kanai, Nobuyuki, Shum, Jeffrey, Garcia, Bertha, Huang, Xuyan, Min, Weiping, Luo, Yigang, Dutartre, Patrick, Zhong, Robert
• Format: Journal Article
• Language: English
• Published: United States 27.04.2003
• Subjects: Animals; Diarrhea - chemically induced; Dose-Response Relationship, Drug; Graft Rejection - prevention & control; Graft Survival - drug effects; Guanidines - administration & dosage; Guanidines - adverse effects; Guanidines - pharmacology; Immunoglobulin G - analysis; Immunoglobulin M - analysis; Immunosuppressive Agents - administration & dosage; Immunosuppressive Agents - adverse effects; Immunosuppressive Agents - pharmacology; Kidney - drug effects; Kidney - pathology; Kidney - physiopathology; Kidney Transplantation; Lymphocyte Count; Macaca fascicularis; Osmolar Concentration; Time Factors; Transplantation, Homologous

LF 15-0195 is a novel, more potent, and less toxic analogue of 15-deoxyspergualin, an antibiotic used as an immunosuppressive agent to prevent rejection of organ transplants. This study was undertaken to determine whether LF 15-0195 monotherapy would prevent renal allograft rejection in a nonhuman p...