Increased Platelet Inhibition After Switching From Maintenance Clopidogrel to Prasugrel in Patients With Acute Coronary Syndromes: Results of the SWAP (Switching Anti Platelet) Study

• Published in: Journal of the American College of Cardiology Vol. 56; no. 13; pp. 1017 - 1023
• Main Authors: ANGIOLILLO, Dominick J, SAUCEDO, Jorge F, DERAAD, Roger, FRELINGER, Andrew L, GURBEL, Paul A, COSTIGAN, Timothy M, JAKUBOWSKI, Joseph A, OJEH, Clement K, EFFRON, Mark B
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier 21.09.2010; Elsevier Limited
• Subjects: Acute Coronary Syndrome - diet therapy; Acute coronary syndromes; Aged; Angioplasty, Balloon, Coronary; Biological and medical sciences; Blood Platelets - drug effects; Cardiology; Cardiology. Vascular system; Coronary heart disease; Coronary vessels; Double-Blind Method; Drug therapy; Female; Heart; Heart attacks; Humans; Male; Medical sciences; Middle Aged; Myocarditis. Cardiomyopathies; Piperazines - administration & dosage; Piperazines - pharmacokinetics; Platelet Aggregation - drug effects; Platelet Aggregation Inhibitors - administration & dosage; Platelet Aggregation Inhibitors - pharmacokinetics; Prasugrel Hydrochloride; Thiophenes - administration & dosage; Thiophenes - pharmacokinetics; Ticlopidine - administration & dosage; Ticlopidine - analogs & derivatives; Ticlopidine - pharmacokinetics; Human; Cardiovascular disease; Patient; Maintenance; Coronary heart disease; Myocardial disease; Switching; Antiplatelet agent; Result; Prasugrel; Platelet; Clopidogrel; Circulatory system; Inhibition; Cardiology; Acute coronary syndrome

The objective was to evaluate the pharmacodynamic response of switching patients on maintenance phase clopidogrel therapy after an acute coronary syndrome (ACS) to prasugrel. Prasugrel P2Y(12) receptor blockade is associated with greater pharmacodynamic platelet inhibition and reduction of ischemic...