Myocardial Ischemia Induced by Rapid Atrial Pacing Causes Troponin T Release Detectable by a Highly Sensitive Assay: Insights From a Coronary Sinus Sampling Study

• Published in: Journal of the American College of Cardiology Vol. 57; no. 24; pp. 2398 - 2405
• Main Authors: TURER, Aslan T, ADDO, Tayo A, DE LEMOS, James A, MARTIN, Justin L, SABATINE, Marc S, LEWIS, Gregory D, GERSZTEN, Robert E, KEELEY, Ellen C, CIGARROA, Joaquin E, LANGE, Richard A, HILLIS, L. David
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier 14.06.2011; Elsevier Limited
• Subjects: Acute coronary syndromes; Adult; Angina Pectoris - blood; Angina Pectoris - therapy; Biological and medical sciences; Biological Assay - methods; Biomarkers; Biomarkers - blood; Cardiac Pacing, Artificial - adverse effects; Cardiac Pacing, Artificial - methods; Cardiology; Cardiology. Vascular system; Cardiovascular disease; Catheters; Coronary Artery Disease - blood; Coronary Artery Disease - diagnosis; Coronary heart disease; Coronary vessels; Electrocardiography; Female; Follow-Up Studies; Heart; Heart attacks; Heart failure; Heart rate; Humans; Ischemia; Kinases; Male; Medical imaging; Medical sciences; Middle Aged; Myocardial Ischemia - blood; Myocardial Ischemia - etiology; Myocarditis. Cardiomyopathies; Pain; Patients; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects); Retrospective Studies; Risk Assessment; Sampling Studies; Sensitivity and Specificity; Severity of Illness Index; Statistical analysis; Statistical methods; Studies; Troponin T - analysis; Troponin T - blood; Samplings; Instrumentation therapy; Cardiovascular disease; Myocardial ischemia; Coronary heart disease; Myocardial disease; Coronary sinus; Troponin T; Vascular disease; Assay; Instrumental stimulation; Circulatory system; Cardiology; Sampling; Release

The purpose of this study was to assess whether: 1) very small increases in troponin T, measured by a new highly sensitive cardiac troponin T (hs-cTnT), may reflect ischemia without necrosis; and 2) serial changes can discriminate ischemia from other causes of cardiac troponin T (cTnT) release. A ne...