A common variant rs2054564 in ADAMST17 is associated with susceptibility to lumbar spondylosis

• Published in: Scientific reports Vol. 13; no. 1; p. 4900
• Main Authors: Taniguchi, Yuki, Akune, Toru, Nishida, Nao, Omori, Go, Ha, Kim, Ueno, Kazuko, Saito, Taku, Oichi, Takeshi, Koike, Asako, Mabuchi, Akihiko, Oka, Hiroyuki, Muraki, Shigeyuki, Oshima, Yasushi, Kawaguchi, Hiroshi, Nakamura, Kozo, Tokunaga, Katsushi, Tanaka, Sakae, Yoshimura, Noriko
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group UK 25.03.2023
• Subjects: Fibrillin-1; Fibrillins - analysis; Genome-Wide Association Study; Humans; Intervertebral Disc - chemistry; Microfibrils; Osteoarthritis, Spine; Spondylosis - genetics

The molecular pathophysiology underlying lumbar spondylosis development remains unclear. To identify genetic factors associated with lumbar spondylosis, we conducted a genome-wide association study using 83 severe lumbar spondylosis cases and 182 healthy controls and identified 65 candidate disease-...