Consensus molecular subtypes of colorectal cancer are recapitulated in in vitro and in vivo models

• Published in: Cell death and differentiation Vol. 25; no. 3; pp. 616 - 633
• Main Authors: Linnekamp, Janneke F., Hooff, Sander R. van, Prasetyanti, Pramudita R., Kandimalla, Raju, Buikhuisen, Joyce Y., Fessler, Evelyn, Ramesh, Prashanthi, Lee, Kelly A. S. T., Bochove, Grehor G. W., de Jong, Johan H., Cameron, Kate, Leersum, Ronald van, Rodermond, Hans M., Franitza, Marek, Nürnberg, Peter, Mangiapane, Laura R., Wang, Xin, Clevers, Hans, Vermeulen, Louis, Stassi, Giorgio, Medema, Jan Paul
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.03.2018; Nature Publishing Group
• Subjects: 631/67/2329; 631/67/70; Apoptosis; Biochemistry; Biomedical and Life Sciences; Cell Biology; Cell Cycle Analysis; Chemotherapy; Colorectal cancer; Colorectal carcinoma; Gene expression; Life Sciences; Mesenchyme; Microsatellite instability; Stem Cells; Tumors; Xenografts
• ISSN: 1350-9047; 1476-5403; 1476-5403
• DOI: 10.1038/s41418-017-0011-5

Colorectal cancer (CRC) is a highly heterogeneous disease both from a molecular and clinical perspective. Several distinct molecular entities, such as microsatellite instability (MSI), have been defined that make up biologically distinct subgroups with their own clinical course. Recent data indicate...