Effects of postoperative sedation with propofol and midazolam on pancreatic function assessed by pancreatitis-associated protein
This prospective randomised controlled study evaluated the effects of postoperative sedation with propofol and midazolam on pancreatic function. We studied 42 intensive care unit patients undergoing elective major surgery who were expected to be sedated postoperatively. Patients were randomly assign...
Saved in:
Published in | Anaesthesia Vol. 56; no. 9; pp. 836 - 840 |
---|---|
Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Oxford
Blackwell
01.09.2001
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | This prospective randomised controlled study evaluated the effects of postoperative sedation with propofol and midazolam on pancreatic function. We studied 42 intensive care unit patients undergoing elective major surgery who were expected to be sedated postoperatively. Patients were randomly assigned to a propofol group (n = 21) or a midazolam group (n = 21). To assess pancreatic function, the following parameters were measured: pancreatitis-associated protein, amylase, lipase, cholesterol and triglyceride prior to start of sedation on the intensive care unit, 4 h after the sedation was started and at the first postoperative day. Patients in the propofol group received on average (SD) 1292 (430) mg propofol and were sedated for 9.03 (4.26) h. The midazolam group received 92 (36) mg midazolam and were sedated for 8.81 (4.68) h. Plasma cholesterol concentrations did not differ significantly between groups. Triglyceride plasma levels 4 h after the start of infusion were significantly higher in the propofol group (140 (54) mg.dl(-1)) than the midazolam-treated patients (81 (29) mg.dl(-1)), but were within normal limits. There were no significant differences between the two groups regarding amylase, lipase and pancreatitis-associated protein plasma concentrations at any time. No markers of pancreatic dysfunction were outside the normal range. We conclude that postoperative sedation with propofol induced a significant increase of serum triglyceride levels but that pancreatic function is unchanged with standard doses of propofol. |
---|---|
AbstractList | This prospective randomised controlled study evaluated the effects of postoperative sedation with propofol and midazolam on pancreatic function. We studied 42 intensive care unit patients undergoing elective major surgery who were expected to be sedated postoperatively. Patients were randomly assigned to a propofol group (n=21) or a midazolam group (n=21). To assess pancreatic function, the following parameters were measured: pancreatitis-associated protein, amylase, lipase, cholesterol and triglyceride prior to start of sedation on the intensive care unit, 4h after the sedation was started and at the first postoperative day. Patients in the propofol group received on average (SD) 1292(430)mg propofol and were sedated for 9.03(4.26)h. The midazolam group received 92(36)mg midazolam and were sedated for 8.81(4.68)h. Plasma cholesterol concentrations did not differ significantly between groups. Triglyceride plasma levels 4h after the start of infusion were significantly higher in the propofol group (140(54)mg.dl super(-1)) than the midazolam-treated patients (81(29)mg.dl super(-1)), but were within normal limits. There were no significant differences between the two groups regarding amylase, lipase and pancreatitis-associated protein plasma concentrations at any time. No markers of pancreatic dysfunction were outside the normal range. We conclude that postoperative sedation with propofol induced a significant increase of serum triglyceride levels but that pancreatic function is unchanged with standard doses of propofol. This prospective randomised controlled study evaluated the effects of postoperative sedation with propofol and midazolam on pancreatic function. We studied 42 intensive care unit patients undergoing elective major surgery who were expected to be sedated postoperatively. Patients were randomly assigned to a propofol group (n = 21) or a midazolam group (n = 21). To assess pancreatic function, the following parameters were measured: pancreatitis-associated protein, amylase, lipase, cholesterol and triglyceride prior to start of sedation on the intensive care unit, 4 h after the sedation was started and at the first postoperative day. Patients in the propofol group received on average (SD) 1292 (430) mg propofol and were sedated for 9.03 (4.26) h. The midazolam group received 92 (36) mg midazolam and were sedated for 8.81 (4.68) h. Plasma cholesterol concentrations did not differ significantly between groups. Triglyceride plasma levels 4 h after the start of infusion were significantly higher in the propofol group (140 (54) mg.dl(-1)) than the midazolam-treated patients (81 (29) mg.dl(-1)), but were within normal limits. There were no significant differences between the two groups regarding amylase, lipase and pancreatitis-associated protein plasma concentrations at any time. No markers of pancreatic dysfunction were outside the normal range. We conclude that postoperative sedation with propofol induced a significant increase of serum triglyceride levels but that pancreatic function is unchanged with standard doses of propofol. |
Author | BOLDT, J MALECK, W. H PIPER, S. N SUTTNER, S. W FENT, M. T KUMLE, B |
Author_xml | – sequence: 1 givenname: S. N surname: PIPER fullname: PIPER, S. N organization: Department, Department of Anaesthesiology and Intensive Care Medicine, Klinikum Ludwigshafen, Bremserstrasse 79, 67063, Ludwigshafen, Germany – sequence: 2 givenname: B surname: KUMLE fullname: KUMLE, B organization: Department, Department of Anaesthesiology and Intensive Care Medicine, Klinikum Ludwigshafen, Bremserstrasse 79, 67063, Ludwigshafen, Germany – sequence: 3 givenname: W. H surname: MALECK fullname: MALECK, W. H organization: Department, Department of Anaesthesiology and Intensive Care Medicine, Klinikum Ludwigshafen, Bremserstrasse 79, 67063, Ludwigshafen, Germany – sequence: 4 givenname: S. W surname: SUTTNER fullname: SUTTNER, S. W organization: Department, Department of Anaesthesiology and Intensive Care Medicine, Klinikum Ludwigshafen, Bremserstrasse 79, 67063, Ludwigshafen, Germany – sequence: 5 givenname: M. T surname: FENT fullname: FENT, M. T organization: Department, Department of Anaesthesiology and Intensive Care Medicine, Klinikum Ludwigshafen, Bremserstrasse 79, 67063, Ludwigshafen, Germany – sequence: 6 givenname: J surname: BOLDT fullname: BOLDT, J organization: Department, Department of Anaesthesiology and Intensive Care Medicine, Klinikum Ludwigshafen, Bremserstrasse 79, 67063, Ludwigshafen, Germany |
BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1106095$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/11531667$$D View this record in MEDLINE/PubMed |
BookMark | eNqFkE1LJDEQhoMoOur-Bclh8dZtpdPpzhxFXF0Q9qLnoZJUMNLdaTuZ3dWTP33DOvtxEwqq4HmqCt5jtj_FiRjjAmoBbXfxVAvZqaqBtq0bAFFDI3pV_9xjq79gn60AQFZNC-sjdpzSUxEbLfQhOxJCSdF1_Yq9XXtPNicePZ9jynGmBXP4TjyRK0Oc-I-QH_m8xDn6OHCcHB-Dw9c44MgLnnGyCxXVcr-d7O8VTIlKOW5e_vEcUlVAtAFzQeVipjCdsgOPQ6JPu37CHr5c31_dVnffbr5eXd5Vc9P1ueqInFm3RijT9h4teqm9Eb0mb40l5xyBAbTagnKaSLaEHWGzJqM0SCVP2Pn73fL3eUspb8aQLA0DThS3adMLIZWQ8KEodFtyFLqIZztxa0Zym3kJIy4vmz_hFuHzTsBkcfBLSSKk_zzoYK3kL-uikT8 |
CODEN | ANASAB |
ContentType | Journal Article |
Copyright | 2001 INIST-CNRS |
Copyright_xml | – notice: 2001 INIST-CNRS |
DBID | IQODW CGR CUY CVF ECM EIF NPM 7U7 C1K 7X8 |
DOI | 10.1046/j.1365-2044.2001.02175.x |
DatabaseName | Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Toxicology Abstracts Environmental Sciences and Pollution Management MEDLINE - Academic |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Toxicology Abstracts Environmental Sciences and Pollution Management MEDLINE - Academic |
DatabaseTitleList | Toxicology Abstracts MEDLINE - Academic MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
EISSN | 1365-2044 |
EndPage | 840 |
ExternalDocumentID | 11531667 1106095 |
Genre | Retracted Publication Comparative Study Clinical Trial Randomized Controlled Trial Journal Article |
GroupedDBID | --- .3N .55 .GA .GJ .Y3 05W 08R 0R~ 10A 1OC 23M 24P 31~ 33P 36B 3O- 3SF 4.4 50Y 50Z 51W 51X 52M 52N 52O 52P 52R 52S 52T 52U 52V 52W 52X 53G 5GY 5HH 5LA 5RE 5VS 66C 6J9 6P2 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A01 A03 AAESR AAEVG AAHHS AAJUZ AANLZ AAONW AAPBV AAQQT AASGY AAUGY AAVGM AAWTL AAXRX AAZKR ABCQN ABCUV ABCVL ABEML ABHUG ABLJU ABPTK ABPVW ABXGK ACAHQ ACCFJ ACCZN ACGFO ACGFS ACGOF ACMXC ACPOU ACPRK ACSCC ACXBN ACXME ACXQS ADAWD ADBBV ADBTR ADDAD ADEOM ADIZJ ADKYN ADMGS ADOZA ADXAS ADZMN ADZOD AEEZP AEGXH AEIGN AEIMD AENEX AEQDE AEUQT AEUYR AFBPY AFEBI AFFNX AFGKR AFPWT AFRAH AFVGU AFZJQ AGJLS AHEFC AHMBA AI. AIACR AIAGR AIURR AIWBW AJBDE AKALU ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN AMBMR AMYDB ATUGU AZBYB AZVAB BAFTC BFHJK BHBCM BMXJE BROTX BRXPI BY8 C45 CAG COF CS3 D-6 D-7 D-E D-F DC6 DCZOG DPXWK DR2 DRFUL DRMAN DRSTM EBS EJD EMOBN ESX EX3 F00 F01 F04 F5P FUBAC FZ0 G-S G.N GODZA H.X HF~ HZI HZ~ IHE IQODW IX1 J0M J5H K48 KBYEO L7B LATKE LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES MEWTI MK4 MRFUL MRMAN MRSTM MSFUL MSMAN MSSTM MXFUL MXMAN MXSTM N04 N05 N9A NF~ O66 O9- OK1 OVD P2P P2W P2X P2Z P4B P4D PQQKQ Q.N Q11 QB0 R.K ROL RX1 SUPJJ TEORI UB1 V8K V9Y VH1 W8V W99 WBKPD WHWMO WIH WIJ WIK WIN WOHZO WOW WQJ WRC WUP WVDHM WXI WXSBR X7M XG1 YFH YOC YUY ZA5 ZCG ZGI ZXP ZZTAW ~IA ~WT ABJNI ABQWH AFFPM AHBTC AITYG CGR CUY CVF ECM EIF HGLYW NPM OIG 7U7 C1K 7X8 |
ID | FETCH-LOGICAL-p267t-6eedb94b15b47facaf38fb178efcbceddde0b0ac8c05d8ee34ea6ea29eb580353 |
ISSN | 0003-2409 |
IngestDate | Fri Aug 16 00:44:00 EDT 2024 Fri Aug 16 22:47:19 EDT 2024 Sat Sep 28 08:38:48 EDT 2024 Sun Oct 22 16:06:03 EDT 2023 |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 9 |
Keywords | Human Postoperative Intensive care Amylase Enzyme Cholesterolemia Toxicity Triacylglycerol lipase Esterases Sedation Carboxylic ester hydrolases Surgery Digestive diseases Hydrolases Benzodiazepine derivatives Midazolam Propofol Sedative Pancreas Comparative study Pancreatic disease Triglyceridemia |
Language | English |
License | CC BY 4.0 |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-p267t-6eedb94b15b47facaf38fb178efcbceddde0b0ac8c05d8ee34ea6ea29eb580353 |
Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Correction/Retraction-3 ObjectType-News-4 |
PMID | 11531667 |
PQID | 18401218 |
PQPubID | 23462 |
PageCount | 5 |
ParticipantIDs | proquest_miscellaneous_71135130 proquest_miscellaneous_18401218 pubmed_primary_11531667 pascalfrancis_primary_1106095 |
PublicationCentury | 2000 |
PublicationDate | 2001-09-01 |
PublicationDateYYYYMMDD | 2001-09-01 |
PublicationDate_xml | – month: 09 year: 2001 text: 2001-09-01 day: 01 |
PublicationDecade | 2000 |
PublicationPlace | Oxford |
PublicationPlace_xml | – name: Oxford – name: England |
PublicationTitle | Anaesthesia |
PublicationTitleAlternate | Anaesthesia |
PublicationYear | 2001 |
Publisher | Blackwell |
Publisher_xml | – name: Blackwell |
References | 21826811 - Anaesthesia. 2011 Jul;66(7):646 |
References_xml | |
SSID | ssj0012818 |
Score | 1.7542022 |
SecondaryResourceType | retracted_publication |
Snippet | This prospective randomised controlled study evaluated the effects of postoperative sedation with propofol and midazolam on pancreatic function. We studied 42... |
SourceID | proquest pubmed pascalfrancis |
SourceType | Aggregation Database Index Database |
StartPage | 836 |
SubjectTerms | Acute-Phase Proteins - metabolism Adult Aged Antigens, Neoplasm Biological and medical sciences Biomarkers - blood Biomarkers, Tumor Cholesterol - blood Conscious Sedation - methods Critical Care - methods Drug toxicity and drugs side effects treatment Female Hemodynamics - drug effects Humans Hypnotics and Sedatives - pharmacology Lectins, C-Type Male Medical sciences Midazolam - pharmacology Middle Aged Pancreas - drug effects Pancreas - physiopathology Pancreatitis-Associated Proteins Pharmacology. Drug treatments Postoperative Care - methods Propofol - pharmacology Prospective Studies Toxicity: digestive system Triglycerides - blood |
Title | Effects of postoperative sedation with propofol and midazolam on pancreatic function assessed by pancreatitis-associated protein |
URI | https://www.ncbi.nlm.nih.gov/pubmed/11531667 https://search.proquest.com/docview/18401218 https://search.proquest.com/docview/71135130 |
Volume | 56 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lj9MwELZguXBBIF4FFnzghoIcO3GS4wq6WsGyIGhFb5HtOKKHJhFJD-yJn85M7DxWbMXjEkVJ5EaZrzNjz-dvCHkJPt9yrougyJjGMmMcpFwBlk0ZppobzlVPkL2QZ-vo3SbeTFzVfndJp1-by2v3lfyPVeEa2BV3yf6DZcdB4QKcg33hCBaG41_ZeDmRMRoUyGis1_FurWuV5JZZG-yEUNZOFGC3LdQlzGd3WCYAV-CyRvMKA5zrGt6XgV1iOt7vtm2gvCUtKgvU2CVzntmeVAoCzDfbbkdH_2nb-LZeU8Hn_X7nCMxjqecDhCjnk79OOyW-7Ltu6AnmOIDj0kQ4cq8mdyuwfJPN3a3TEfewyma-MxVyHoaditNvHp710sYDPY9F_boY6q5CHjQwP-ei2hcf89P1-Xm-Wm5WN8ktnmQxMj_ffh5VxrCWmA6NFfFtPeHLF7-v_R2k0KoW_kWla39yeH7S5ymru-SOn2DQE4eWe-SGre6Tnx4ptC7pFaTQASkUkUIHpFBACh2RQuH2hBQ6IIUOSKH6Bz2AFOqR8oCsT5erN2eB770RNFwmXSAhd9JZpMNYR0mpjCpFWuowSW1ptLEFREWmmTKpYXGRWisiq6RVPLM6TpmIxUNyVNWVfUwoD2XBWRFqhVpX1mgtIW3XopSch8LYBTm-8i3zxumswOSUoRzigrwYvm0Ovg8LWqqy9b7NcXUihBz18BNJiB0oBVuQR84os8Eh-kiZPPnj6E_J7Qncz8hR931vjyET7fTzHke_AL0WkGo |
link.rule.ids | 315,786,790,27955,27956 |
linkProvider | Wiley-Blackwell |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Effects+of+postoperative+sedation+with+propofol+and+midazolam+on+pancreatic+function+assessed+by+pancreatitis-associated+protein&rft.jtitle=Anaesthesia&rft.au=Piper%2C+S+N&rft.au=Kumle%2C+B&rft.au=Maleck%2C+W+H&rft.au=Suttner%2C+S+W&rft.date=2001-09-01&rft.issn=0003-2409&rft.volume=56&rft.issue=9&rft.spage=836&rft.epage=840&rft_id=info:doi/10.1046%2Fj.1365-2044.2001.02175.x&rft.externalDBID=NO_FULL_TEXT |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0003-2409&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0003-2409&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0003-2409&client=summon |