Anti-tissue remodeling effects of corticosteroids: Fluticasone propionate inhibits fibronectin expression in fibroblasts

• Published in: Chest Vol. 127; no. 1; pp. 257 - 265
• Main Authors: TOMIC, Rade, LASSITER, Charles C, RITZENTHALER, Jeffrey D, RIVERA, Hilda N, ROMAN, Jesse
• Format: Journal Article
• Language: English
• Published: Northbrook, IL American College of Chest Physicians 2005
• Subjects: Activating Transcription Factor 1; Adenosine; Androstadienes - pharmacology; Anti-Inflammatory Agents - pharmacology; Antibiotics; Antibodies; Asthma; Biological and medical sciences; Blotting, Western; Bones, joints and connective tissue. Antiinflammatory agents; Cardiology. Vascular system; Dehydrogenases; DNA-Binding Proteins - physiology; Dose-Response Relationship, Drug; Electrophoretic Mobility Shift Assay; Extracellular matrix; Fibroblasts; Fibroblasts - metabolism; Fibronectins - genetics; Fibronectins - metabolism; Fluticasone; Gene Expression; Glycoproteins; Humans; Lung - metabolism; Lung diseases; Medical sciences; Nicotine; Penicillin; Pharmacology. Drug treatments; Phosphorylation; Pneumology; Polymerase chain reaction; Proteins; Steroids; Tobacco; Transcription factors; Transcription Factors - physiology; Transcription, Genetic; Corticosteroid; Adenosine; gene transcription; remodeling; Transcription; Respiratory disease; Cardiovascular disease; Fluticasone; cyclic adenosine monophosphate response element binding protein; Elements; Gene expression; matrix; Fibronectin; Vascular remodeling; Response; Binding protein; Tissue; fibroblasts; Gene; Cyclic; Fibroblast; Nicotine

Tissue remodeling often accompanies diseases such as COPD that are caused by or aggravated by tobacco exposure. Inhaled or systemic corticosteroids are frequently used for the treatment of these illnesses, and their beneficial effects are often ascribed to their anti-inflammatory properties. However...