The effect of adjuvants on immune function in the multi-low-dose streptozotocin model of murine diabetes

• Published in: International journal on tissue reactions Vol. 10; no. 4; p. 207
• Main Authors: Richens, E R, Behbehani, K
• Format: Journal Article
• Language: English
• Published: Switzerland 1988
• Subjects: Adjuvants, Immunologic - pharmacology; Animals; Antibodies - analysis; Blood Glucose - metabolism; Body Weight - drug effects; Cells, Cultured; Diabetes Mellitus, Experimental - blood; Diabetes Mellitus, Experimental - immunology; Diabetes Mellitus, Experimental - therapy; Fluorescent Antibody Technique; Male; Mice; Mice, Inbred C57BL; Mice, Inbred CBA

The effect of various adjuvants has been investigated on the multi-low-dose (mld) streptozotocin (STZ) model of diabetes in C57BL/6 and CBA mice; diabetes was severe in the former strain. Diabetic levels of glycaemia were not attained in either strain using half the mld STZ dose (sub-mld-STZ). The a...