Yes associated protein is a poor prognostic factor in well-differentiated lung adenocarcinoma

• Published in: International journal of clinical and experimental pathology Vol. 8; no. 12; pp. 15933 - 15939
• Main Authors: Kim, Mi Hyun, Kim, Young Keum, Shin, Dong Hoon, Lee, Hyun Jeong, Shin, Nari, Kim, Arong, Lee, Jung Hee, Choi, Kyung Un, Kim, Jee Yeon, Lee, Chang Hun, Sol, Mee Young
• Format: Journal Article
• Language: English
• Published: United States e-Century Publishing Corporation 01.01.2015
• Subjects: Adaptor Proteins, Signal Transducing - analysis; Adenocarcinoma - chemistry; Adenocarcinoma - mortality; Adenocarcinoma - pathology; Adenocarcinoma - surgery; Adenocarcinoma of Lung; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor - analysis; Cell Differentiation; Cell Nucleus - chemistry; Cytoplasm - chemistry; Disease Progression; Disease-Free Survival; Female; Humans; Kaplan-Meier Estimate; Lung Neoplasms - chemistry; Lung Neoplasms - mortality; Lung Neoplasms - pathology; Lung Neoplasms - surgery; Male; Middle Aged; Oncogene Proteins - analysis; Original; Phosphoproteins - analysis; Risk Factors; Time Factors; Transcription Factors; Treatment Outcome; YAP; adenocarcinoma; hippo pathway; Lung; LATS

The Hippo pathway is a highly conserved potent regulator of cell growth and apoptosis including large tumor suppressor (LATS) and Yes-associated protein (YAP). LATS has been regarded as a tumor suppressor gene and YAP as either of a tumor suppressor gene or an oncogene. We investigated their express...