Current Controversies: Are Free Vitamin Metabolite Levels a More Accurate Assessment of Vitamin D Status than Total Levels?

• Published in: Endocrinology and metabolism clinics of North America Vol. 46; no. 4; p. 901
• Main Authors: Bikle, Daniel D, Malmstroem, Sofie, Schwartz, Janice
• Format: Journal Article
• Language: English
• Published: United States 01.12.2017
• Subjects: Humans; Vitamin D - analogs & derivatives; Vitamin D - blood; Vitamin D Deficiency - blood; Vitamin D Deficiency - diagnosis; Free hormone hypothesis; Pregnancy; Vitamin D metabolism; Vitamin D; Liver disease; Free vitamin D

The free hormone hypothesis postulates that only the nonbound fraction (the free fraction) of hormones that otherwise circulate in blood bound to their carrier proteins is able to enter cells and exert their biologic effects. For the vitamin D metabolites less than 1% (0.4% for 1,25(OH) D and 0.03%...